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A method for assessing carcinogenic risk of air fine particle-associated polycyclic aromatic hydrocarbons by considering bioaccessibility in lung fluids
This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. Only limit PAHs in particles can be released in simulated lung fluids, leading to a low bioacces...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439207/ https://www.ncbi.nlm.nih.gov/pubmed/30976529 http://dx.doi.org/10.1016/j.mex.2019.03.009 |
Sumario: | This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. Only limit PAHs in particles can be released in simulated lung fluids, leading to a low bioaccessibility (only ranging from 0.34% to 1.48% for biochar fine particles and from 3.21% to 44.2% for PM(2.5)), which would significantly affect health risk assessment. Therefore, bioaccessibility should always be favored over more traditional evaluations based on total concentration, while evaluating inhalation health risks of biochar-bound PAHs. To prove the broad applicability of bioaccessibility-based assessment approaches, we also compared health risk of actual atmospheric particles (PM(2.5) collected from Nanjing, China) using total concentration-based approaches and bioaccessibility-based approaches. • Proposed bioaccessibility-based approaches for assessing biochar risk are more accurate than traditional total concentration-based approaches; • Proposed bioaccessibility-based approaches can be applied to health risk assessment of actual air particles; • A more practical method was proposed to evaluate the bioaccessibility of PAHs in biochar fine particles or other specific component of atmospheric particle matters: using wet sieving method to prepare fine particles, using volatile organic solvent-drying method to load (14)C-PAHs on fine particles, and using desorption experiments to determine bioaccessibility of PAHs. |
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