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Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying mechanism. The pressure-volume loop, isolated heart, and Ca(2+) transients triggered by field stimulation or caffe...

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Detalles Bibliográficos
Autores principales:	Huang, Huili, Xie, Ming, Gao, Li, Zhang, Wenhui, Zhu, Xiaojia, Wang, Yuwei, Li, Wei, Wang, Rongrong, Chen, Kesu, Boutjdir, Mohamed, Chen, Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439224/ https://www.ncbi.nlm.nih.gov/pubmed/30967774 http://dx.doi.org/10.3389/fphar.2019.00221

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