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Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons

G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the possibility of developing drugs with improved efficacy and safety profiles, yet translating this concept to native tissues remains a major challe...

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Detalles Bibliográficos
Autores principales:	Ehrlich, Aliza T., Semache, Meriem, Gross, Florence, Da Fonte, Dillon F., Runtz, Leonie, Colley, Christine, Mezni, Amina, Le Gouill, Christian, Lukasheva, Viktoriya, Hogue, Mireille, Darcq, Emmanuel, Bouvier, Michel, Kieffer, Brigitte L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439305/ https://www.ncbi.nlm.nih.gov/pubmed/30925410 http://dx.doi.org/10.1016/j.isci.2019.03.011

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