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E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer
E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that aberrant expression or activation of E2Fs is a common phenomenon in malignances, and significant associations have been noted between E2Fs and tumorigenesis or progression in a wide range of cancers. However, th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439355/ https://www.ncbi.nlm.nih.gov/pubmed/30967995 http://dx.doi.org/10.3389/fonc.2019.00161 |
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author | Zhou, Quan Zhang, Fan He, Ze Zuo, Man-Zhen |
author_facet | Zhou, Quan Zhang, Fan He, Ze Zuo, Man-Zhen |
author_sort | Zhou, Quan |
collection | PubMed |
description | E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that aberrant expression or activation of E2Fs is a common phenomenon in malignances, and significant associations have been noted between E2Fs and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of each E2F contributing to tumorigenesis and progression of ovarian cancer (OC) have not yet been elucidated. In this study, we investigated the distinct expression and prognostic value of E2Fs in patients with OC by analyzing a series of databases, including ONCOMINE, GEPIA, cBioPortal, Metascape, and Kaplan–Meier plotter. The mRNA expression levels of E2F1/3/5/8 were found to be significantly upregulated in patients with OC and were obviously associated with tumor stage for OC. Aberrant expression of E2F2/5/7/8 was found to be associated with the clinical outcomes of patients with OC. These results suggest that E2F2/5/8 might serve as potential prognostic biomarkers and targets for OC. However, future studies are required to validate our findings and promote the clinical utility of E2Fs in OC. |
format | Online Article Text |
id | pubmed-6439355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64393552019-04-09 E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer Zhou, Quan Zhang, Fan He, Ze Zuo, Man-Zhen Front Oncol Oncology E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that aberrant expression or activation of E2Fs is a common phenomenon in malignances, and significant associations have been noted between E2Fs and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of each E2F contributing to tumorigenesis and progression of ovarian cancer (OC) have not yet been elucidated. In this study, we investigated the distinct expression and prognostic value of E2Fs in patients with OC by analyzing a series of databases, including ONCOMINE, GEPIA, cBioPortal, Metascape, and Kaplan–Meier plotter. The mRNA expression levels of E2F1/3/5/8 were found to be significantly upregulated in patients with OC and were obviously associated with tumor stage for OC. Aberrant expression of E2F2/5/7/8 was found to be associated with the clinical outcomes of patients with OC. These results suggest that E2F2/5/8 might serve as potential prognostic biomarkers and targets for OC. However, future studies are required to validate our findings and promote the clinical utility of E2Fs in OC. Frontiers Media S.A. 2019-03-22 /pmc/articles/PMC6439355/ /pubmed/30967995 http://dx.doi.org/10.3389/fonc.2019.00161 Text en Copyright © 2019 Zhou, Zhang, He and Zuo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhou, Quan Zhang, Fan He, Ze Zuo, Man-Zhen E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title | E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title_full | E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title_fullStr | E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title_full_unstemmed | E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title_short | E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer |
title_sort | e2f2/5/8 serve as potential prognostic biomarkers and targets for human ovarian cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439355/ https://www.ncbi.nlm.nih.gov/pubmed/30967995 http://dx.doi.org/10.3389/fonc.2019.00161 |
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