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Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies
BACKGROUND: There is increasing evidence linking alterations of the gut microbial composition during early infancy to the development of atopic diseases and asthma. However, few studies have addressed the association of dysbiotic gut microbiota with allergic reactions through evaluation of feces in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439417/ https://www.ncbi.nlm.nih.gov/pubmed/30937143 http://dx.doi.org/10.1016/j.waojou.2019.100021 |
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author | Chiu, Chih-Yung Chan, Yi-Ling Tsai, Ming-Han Wang, Chia-Jung Chiang, Meng-Han Chiu, Chun-Che |
author_facet | Chiu, Chih-Yung Chan, Yi-Ling Tsai, Ming-Han Wang, Chia-Jung Chiang, Meng-Han Chiu, Chun-Che |
author_sort | Chiu, Chih-Yung |
collection | PubMed |
description | BACKGROUND: There is increasing evidence linking alterations of the gut microbial composition during early infancy to the development of atopic diseases and asthma. However, few studies have addressed the association of dysbiotic gut microbiota with allergic reactions through evaluation of feces in young children with allergic airway diseases. METHODS: We sought to evaluate relationships among gut microbiota, total fecal immunoglobulin E (IgE) levels, serum allergic sensitization, and their relevance to childhood allergic rhinitis and asthma. Microbial composition and diversity were analyzed with Illumina-based 16S rRNA gene sequencing of 89 stool samples collected from children with asthma (n = 35) and allergic rhinitis (n = 28), and from healthy controls (n = 26). Data analysis was performed using Quantitative Insights into Microbial Ecology (QIIME) software. RESULTS: A significantly lower abundance of organisms of the phylum Firmicutes were found in children with asthma and allergic rhinitis than in the healthy controls. Relatively lower Chao1 and Shannon indices were also found in children with allergic airway diseases but without any significant difference. Total fecal IgE levels in early childhood were strongly correlated with serum D. pteronyssinus- and D. farinae-specific IgE but not with food-specific IgE levels. In comparison with healthy controls, the genus Dorea was less abundant and negatively correlated with total fecal IgE levels in children with rhinitis, whereas the genus Clostridium was abundant and positively correlated with fecal IgE levels in children with asthma. CONCLUSIONS: An interaction between particular subsets of gut microbial dysbiosis and IgE-mediated responses to allergens may contribute to the susceptibility to allergic rhinitis and asthma in early childhood. |
format | Online Article Text |
id | pubmed-6439417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-64394172019-04-01 Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies Chiu, Chih-Yung Chan, Yi-Ling Tsai, Ming-Han Wang, Chia-Jung Chiang, Meng-Han Chiu, Chun-Che World Allergy Organ J Article BACKGROUND: There is increasing evidence linking alterations of the gut microbial composition during early infancy to the development of atopic diseases and asthma. However, few studies have addressed the association of dysbiotic gut microbiota with allergic reactions through evaluation of feces in young children with allergic airway diseases. METHODS: We sought to evaluate relationships among gut microbiota, total fecal immunoglobulin E (IgE) levels, serum allergic sensitization, and their relevance to childhood allergic rhinitis and asthma. Microbial composition and diversity were analyzed with Illumina-based 16S rRNA gene sequencing of 89 stool samples collected from children with asthma (n = 35) and allergic rhinitis (n = 28), and from healthy controls (n = 26). Data analysis was performed using Quantitative Insights into Microbial Ecology (QIIME) software. RESULTS: A significantly lower abundance of organisms of the phylum Firmicutes were found in children with asthma and allergic rhinitis than in the healthy controls. Relatively lower Chao1 and Shannon indices were also found in children with allergic airway diseases but without any significant difference. Total fecal IgE levels in early childhood were strongly correlated with serum D. pteronyssinus- and D. farinae-specific IgE but not with food-specific IgE levels. In comparison with healthy controls, the genus Dorea was less abundant and negatively correlated with total fecal IgE levels in children with rhinitis, whereas the genus Clostridium was abundant and positively correlated with fecal IgE levels in children with asthma. CONCLUSIONS: An interaction between particular subsets of gut microbial dysbiosis and IgE-mediated responses to allergens may contribute to the susceptibility to allergic rhinitis and asthma in early childhood. World Allergy Organization 2019-03-25 /pmc/articles/PMC6439417/ /pubmed/30937143 http://dx.doi.org/10.1016/j.waojou.2019.100021 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiu, Chih-Yung Chan, Yi-Ling Tsai, Ming-Han Wang, Chia-Jung Chiang, Meng-Han Chiu, Chun-Che Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title | Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title_full | Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title_fullStr | Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title_full_unstemmed | Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title_short | Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies |
title_sort | gut microbial dysbiosis is associated with allergen-specific ige responses in young children with airway allergies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439417/ https://www.ncbi.nlm.nih.gov/pubmed/30937143 http://dx.doi.org/10.1016/j.waojou.2019.100021 |
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