Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

[Image: see text] Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions. Streptococcus pyogenes secretes a unique endo-β-N-acetylglucosaminidase, EndoS2, which deglycosylates the conserved N-linked glycan at Asn297 on IgG Fc to eliminate its effector functions and eva...

Descripción completa

Detalles Bibliográficos
Autores principales: Klontz, Erik H., Trastoy, Beatriz, Deredge, Daniel, Fields, James K., Li, Chao, Orwenyo, Jared, Marina, Alberto, Beadenkopf, Robert, Günther, Sebastian, Flores, Jair, Wintrode, Patrick L., Wang, Lai-Xi, Guerin, Marcelo E., Sundberg, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439443/
https://www.ncbi.nlm.nih.gov/pubmed/30937380
http://dx.doi.org/10.1021/acscentsci.8b00917

Ejemplares similares

Ejemplares similares