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Crosstalk between tumor cells and lymphocytes modulates heparanase expression

BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans. The oligosaccharides generated by HPSE promote angiogenesis, tumor growth and metastasis. Heparanase-2 (HPSE2), a close homolog of HPSE, does not exhibit catalytic activity. Previo...

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Detalles Bibliográficos
Autores principales:	Theodoro, Thérèse Rachell, Matos, Leandro Luongo, Cavalheiro, Renan Pelluzzi, Justo, Giselle Zenker, Nader, Helena Bonciani, Pinhal, Maria Aparecida Silva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439996/ https://www.ncbi.nlm.nih.gov/pubmed/30922347 http://dx.doi.org/10.1186/s12967-019-1853-z

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