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Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients

BACKGROUND: Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining c...

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Autores principales: Broers, Natascha J. H., Fung, Tsz Yeung, Kooman, Jeroen P., Christiaans, Maarten H. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440145/
https://www.ncbi.nlm.nih.gov/pubmed/30922268
http://dx.doi.org/10.1186/s12882-019-1299-9
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author Broers, Natascha J. H.
Fung, Tsz Yeung
Kooman, Jeroen P.
Christiaans, Maarten H. L.
author_facet Broers, Natascha J. H.
Fung, Tsz Yeung
Kooman, Jeroen P.
Christiaans, Maarten H. L.
author_sort Broers, Natascha J. H.
collection PubMed
description BACKGROUND: Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining changes in these parameters in the first post-operative year in both groups. METHODS: Twenty-two kidney transplant recipients and 22 healthy kidney donors were included in this prospective longitudinal study with a follow-up until twelve months. PF was assessed by handgrip strength (HGS), and by the physical domains of health-related quality of life (HRQOL) using the Short Form-36 questionnaire [PF (SF-36 PF) and physical component summary (PCS) score]. BC was measured by the Body Composition Monitor©, and PA was measured by the SenseWear™ pro3. RESULTS: At baseline, recipients had significantly lower HGS (after adjustment for sex and body weight), SF-36 PF, PCS, and PA, as compared with their donors. In recipients HGS significantly increased in the first year after transplantation, but PA did not change in the first six months after transplantation. Furthermore, no significant increase in lean tissue mass was observed. For healthy donors no significant changes in these parameters were observed, with exception of SF-36 PF, which declined in the first three months after donation, but equaled baseline values after twelve months. CONCLUSION: Recipients showed impressive improvements in PF and the physical domains of HRQOL in the first year after transplantation, reaching levels of healthy kidney donors already three to six months after transplantation. On the contrary, living kidney donation did not show any deterioration of the investigated parameters, supporting little impact for well-screened donors, while there is high benefit for transplant recipients.
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spelling pubmed-64401452019-04-11 Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients Broers, Natascha J. H. Fung, Tsz Yeung Kooman, Jeroen P. Christiaans, Maarten H. L. BMC Nephrol Research Article BACKGROUND: Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining changes in these parameters in the first post-operative year in both groups. METHODS: Twenty-two kidney transplant recipients and 22 healthy kidney donors were included in this prospective longitudinal study with a follow-up until twelve months. PF was assessed by handgrip strength (HGS), and by the physical domains of health-related quality of life (HRQOL) using the Short Form-36 questionnaire [PF (SF-36 PF) and physical component summary (PCS) score]. BC was measured by the Body Composition Monitor©, and PA was measured by the SenseWear™ pro3. RESULTS: At baseline, recipients had significantly lower HGS (after adjustment for sex and body weight), SF-36 PF, PCS, and PA, as compared with their donors. In recipients HGS significantly increased in the first year after transplantation, but PA did not change in the first six months after transplantation. Furthermore, no significant increase in lean tissue mass was observed. For healthy donors no significant changes in these parameters were observed, with exception of SF-36 PF, which declined in the first three months after donation, but equaled baseline values after twelve months. CONCLUSION: Recipients showed impressive improvements in PF and the physical domains of HRQOL in the first year after transplantation, reaching levels of healthy kidney donors already three to six months after transplantation. On the contrary, living kidney donation did not show any deterioration of the investigated parameters, supporting little impact for well-screened donors, while there is high benefit for transplant recipients. BioMed Central 2019-03-29 /pmc/articles/PMC6440145/ /pubmed/30922268 http://dx.doi.org/10.1186/s12882-019-1299-9 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Broers, Natascha J. H.
Fung, Tsz Yeung
Kooman, Jeroen P.
Christiaans, Maarten H. L.
Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title_full Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title_fullStr Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title_full_unstemmed Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title_short Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
title_sort living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440145/
https://www.ncbi.nlm.nih.gov/pubmed/30922268
http://dx.doi.org/10.1186/s12882-019-1299-9
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