Phenothiazine normalizes the NADH/NAD(+) ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease

Impaired mitochondrial function has been associated with the etiopathogenesis of Parkinson's disease (PD). Sustained inhibition of complex I produces mitochondrial dysfunction, which is related to oxidative injury and nigrostriatal dopamine (DA) neurodegeneration. This study aimed to identify d...

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Detalles Bibliográficos
Autores principales: Tapias, Victor, McCoy, Jennifer L., Greenamyre, J. Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440170/
https://www.ncbi.nlm.nih.gov/pubmed/30925294
http://dx.doi.org/10.1016/j.redox.2019.101164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440170/
https://www.ncbi.nlm.nih.gov/pubmed/30925294
http://dx.doi.org/10.1016/j.redox.2019.101164

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