Cargando…

Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis

Rheumatoid arthritis (RA) is characterized by chronic progressive symmetrical synovitis and destruction of multiple joints. Glucocorticoids (GCs) are widely used in the treatment of RA. However, their adverse effects can be serious. Escin, which is isolated from Aesculus hippocastanum L., has been r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Leiming, Huang, Yanan, Wu, Chuanhong, Du, Yuan, Li, Peng, Wang, Meiling, Wang, Xinlin, Wang, Yanfang, Hao, Yanfei, Wang, Tian, Fan, Baofeng, Gao, Zhuye, Fu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440172/ https://www.ncbi.nlm.nih.gov/pubmed/30967782 http://dx.doi.org/10.3389/fphar.2019.00280

Ejemplares similares

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis
por: Wang, Meiling, et al.
Publicado: (2020)

Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug
por: Gallelli, Luca, et al.
Publicado: (2021)

Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-κB signaling pathway, but not the COX/PGF2α signaling pathway
por: WANG, HONGSHENG, et al.
Publicado: (2013)

Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models
por: Li, Minmin, et al.
Publicado: (2015)

Network Pharmacology-Based Prediction of Active Ingredients and Mechanisms of Lamiophlomis rotata (Benth.) Kudo Against Rheumatoid Arthritis
por: Jiang, Yunbin, et al.
Publicado: (2019)

An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis
por: Wu, Jie, et al.
Publicado: (2022)

Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study
por: Li, Xi, et al.
Publicado: (2023)

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation
por: Guo, Qingqing, et al.
Publicado: (2017)

Consistency of recommendations for pharmacotherapy of rheumatoid arthritis
por: Hu, Yue, et al.
Publicado: (2022)

Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation
por: Shi, Lu, et al.
Publicado: (2022)

Corrigendum: An integrative pharmacology model for decoding the underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid arthritis
por: Wu, Jie, et al.
Publicado: (2023)

Detecting potential mechanism of vitamin D in treating rheumatoid arthritis based on network pharmacology and molecular docking
por: Xu, Xiaoyu, et al.
Publicado: (2022)

Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model
por: Wang, Ke-xin, et al.
Publicado: (2020)

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
por: Aihaiti, Yirixiati, et al.
Publicado: (2021)

Network analysis combined with pharmacological evaluation strategy to reveal the mechanism of Tibetan medicine Wuwei Shexiang pills in treating rheumatoid arthritis
por: He, Qingxiu, et al.
Publicado: (2022)

Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells
por: Sun, Yueshan, et al.
Publicado: (2020)

Gaultheria leucocarpa var. yunnanensis for Treating Rheumatoid Arthritis—An Assessment Combining Machine Learning–Guided ADME Properties Prediction, Network Pharmacology, and Pharmacological Assessment
por: Wang, Xiuhuan, et al.
Publicado: (2021)

Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes
por: Hosoya, Tadashi, et al.
Publicado: (2020)

Identification of the Main Active Components and Mechanism of Wang Bi Tablet in Treating Rheumatoid Arthritis Based on Integrative Pharmacology
por: Jiao, Yuanyuan, et al.
Publicado: (2021)

Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis
por: Ji, Mingyue, et al.
Publicado: (2021)

Clinical Evidence-Guided Anti-rheumatoid Arthritis Study of Shuji Tablet in Adjuvant-Induced Arthritis Rats and Mechanism Exploration via Network Pharmacological Approach
por: Dai, Weibo, et al.
Publicado: (2021)

Immunomodulatory roles of metalloproteinases in rheumatoid arthritis
por: Bian, Yanqin, et al.
Publicado: (2023)

Glucocorticoid management in rheumatoid arthritis: morning or night low dose?
por: Paolino, Sabrina, et al.
Publicado: (2017)

The role of resveratrol on rheumatoid arthritis: From bench to bedside
por: Sheng, Shuyan, et al.
Publicado: (2022)

Glucocorticoids and chronotherapy in rheumatoid arthritis
por: Cutolo, Maurizio
Publicado: (2016)

Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis
por: Xin, Pan Lin, et al.
Publicado: (2021)

Anti-Rheumatoid Arthritic Effects of Paris Saponin VII in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Adjuvant-Induced Arthritis in Rats
por: Meng, Mei, et al.
Publicado: (2021)

Benefits and risks of low-dose glucocorticoid treatment in the patient with rheumatoid arthritis
por: Kavanaugh, Arthur, et al.
Publicado: (2014)

The supplementary therapeutic DMARD role of low-dose glucocorticoids in rheumatoid arthritis
por: Cutolo, Maurizio, et al.
Publicado: (2014)

The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
por: Zhang, Leiming, et al.
Publicado: (2021)

Identification of Tumor Necrosis Factor-Alpha (TNF-α) Inhibitor in Rheumatoid Arthritis Using Network Pharmacology and Molecular Docking
por: Bai, Liang Liang, et al.
Publicado: (2021)

A Role of IL-17 in Rheumatoid Arthritis Patients Complicated With Atherosclerosis
por: Wang, Jiexin, et al.
Publicado: (2022)

The positive clinical therapeutically effects of Escin on advanced thyroid cancer
por: Mei, Jin‐Yu, et al.
Publicado: (2017)

Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Cornus Officinalis and Paeonia Lactiflora in Rheumatoid Arthritis via Network Pharmacology Analysis
por: Li, Qinglin, et al.
Publicado: (2021)

Mercury and Mercury-Containing Preparations: History of Use, Clinical Applications, Pharmacology, Toxicology, and Pharmacokinetics in Traditional Chinese Medicine
por: Zhao, Meiling, et al.
Publicado: (2022)

Computational Prediction of Antiangiogenesis Synergistic Mechanisms of Total Saponins of Panax japonicus Against Rheumatoid Arthritis
por: Guo, Xiang, et al.
Publicado: (2020)

Uridine Diphosphate Promotes Rheumatoid Arthritis Through P2Y6 Activation
por: Wang, Hongxing, et al.
Publicado: (2021)

Rheumatoid arthritis - a neuroendocrine immune disorder: glucocorticoid resistance, relative glucocorticoid deficiency, low-dose glucocorticoid therapy, and insulin resistance
por: Straub, Rainer H
Publicado: (2014)

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation
por: Yao, Yao, et al.
Publicado: (2020)

Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis
por: Chen, Xiaochen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j0l2m4sg24sr6n6qdhf8orbklh