Vitiligoid hypopigmentation associated with pembrolizumab in metastatic head and neck cancer

Cutaneous adverse events are common with the use of immunotherapy. Although only 5% of patients develop severe reactions, about half will develop mild to moderate cutaneous adverse events. Vitiligo has been seen in melanomas treated with checkpoint inhibitors (CPI). We describe the first known case of Vitiligoid irAE (immune-related adverse event) in a non-melanoma solid cancer treated with pembrolizumab.