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Post-Renal Transplant Metabolic Acidosis: A Neglected Entity

Metabolic acidosis is a prevalent yet overlooked entity among renal transplant recipients (RTRs) and incurs adverse effects on graft function. Although graft dysfunction and calcineurin inhibitor usage have been linked with renal tubular acidosis (RTA), there is no Indian data on prevalence or risk...

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Autores principales: Fernando, M. E., Jayanivash, J., Srinivasaprasad, N. D., Suren, S., Thirumalvalavan, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440336/
https://www.ncbi.nlm.nih.gov/pubmed/30983752
http://dx.doi.org/10.4103/ijn.IJN_93_18
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author Fernando, M. E.
Jayanivash, J.
Srinivasaprasad, N. D.
Suren, S.
Thirumalvalavan, K.
author_facet Fernando, M. E.
Jayanivash, J.
Srinivasaprasad, N. D.
Suren, S.
Thirumalvalavan, K.
author_sort Fernando, M. E.
collection PubMed
description Metabolic acidosis is a prevalent yet overlooked entity among renal transplant recipients (RTRs) and incurs adverse effects on graft function. Although graft dysfunction and calcineurin inhibitor usage have been linked with renal tubular acidosis (RTA), there is no Indian data on prevalence or risk factors of post-transplant acidosis. A cross-sectional study was conducted on 106 adult RTRs, with a transplant duration of >6 months and an estimated glomerular filtration rate (GFR) >40 ml/min/1.73 m(2). Acidosis was diagnosed on basis of plasma bicarbonate and arterial pH. Serum and urine electrolytes with anion gap were determined to diagnose and type RTA. Acidosis was diagnosed in 44 of 106 patients (41.5%) with 23 (52.27%) having severe acidosis. Type I RTA was the most common subtype (52.5%) followed by type IV (30.9%) and type II RTA (7.5%). The correlation between estimated glomerular filtration rate and acidosis was minimally linear (r = 0.1088), with multivariate analysis revealing previous acute rejection episodes, current serum tacrolimus levels, cotrimoxazole usage and intake of animal proteins to be independent risk factors. The serum albumin levels were low in the acidosis group and showed linear correlation with bicarbonate levels (r = 0.298). There is a high prevalence of metabolic acidosis in RTRs with type I RTA being most common subtype. Screening of RTRs on a regular basis is a feasible approach for early diagnosis and intervention. However, prospective studies are needed to demonstrate the effect of acidosis on graft survival and benefit of bicarbonate therapy in RTRs.
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spelling pubmed-64403362019-04-12 Post-Renal Transplant Metabolic Acidosis: A Neglected Entity Fernando, M. E. Jayanivash, J. Srinivasaprasad, N. D. Suren, S. Thirumalvalavan, K. Indian J Nephrol Original Article Metabolic acidosis is a prevalent yet overlooked entity among renal transplant recipients (RTRs) and incurs adverse effects on graft function. Although graft dysfunction and calcineurin inhibitor usage have been linked with renal tubular acidosis (RTA), there is no Indian data on prevalence or risk factors of post-transplant acidosis. A cross-sectional study was conducted on 106 adult RTRs, with a transplant duration of >6 months and an estimated glomerular filtration rate (GFR) >40 ml/min/1.73 m(2). Acidosis was diagnosed on basis of plasma bicarbonate and arterial pH. Serum and urine electrolytes with anion gap were determined to diagnose and type RTA. Acidosis was diagnosed in 44 of 106 patients (41.5%) with 23 (52.27%) having severe acidosis. Type I RTA was the most common subtype (52.5%) followed by type IV (30.9%) and type II RTA (7.5%). The correlation between estimated glomerular filtration rate and acidosis was minimally linear (r = 0.1088), with multivariate analysis revealing previous acute rejection episodes, current serum tacrolimus levels, cotrimoxazole usage and intake of animal proteins to be independent risk factors. The serum albumin levels were low in the acidosis group and showed linear correlation with bicarbonate levels (r = 0.298). There is a high prevalence of metabolic acidosis in RTRs with type I RTA being most common subtype. Screening of RTRs on a regular basis is a feasible approach for early diagnosis and intervention. However, prospective studies are needed to demonstrate the effect of acidosis on graft survival and benefit of bicarbonate therapy in RTRs. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6440336/ /pubmed/30983752 http://dx.doi.org/10.4103/ijn.IJN_93_18 Text en Copyright: © 2019 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Fernando, M. E.
Jayanivash, J.
Srinivasaprasad, N. D.
Suren, S.
Thirumalvalavan, K.
Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title_full Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title_fullStr Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title_full_unstemmed Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title_short Post-Renal Transplant Metabolic Acidosis: A Neglected Entity
title_sort post-renal transplant metabolic acidosis: a neglected entity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440336/
https://www.ncbi.nlm.nih.gov/pubmed/30983752
http://dx.doi.org/10.4103/ijn.IJN_93_18
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