Cargando…

Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons

We investigated effects of the neuroactive steroid anesthetic alfaxalone on intrinsic excitability, and on inhibitory and excitatory synaptic transmission to hypoglossal motor neurons (HMNs). Whole cell recordings were made from HMNs in brainstem slices from 7 to 14-day-old Wistar rats. Spontaneous,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lau, Cora, Thakre, Prajwal P., Bellingham, Mark C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440435/ https://www.ncbi.nlm.nih.gov/pubmed/30967762 http://dx.doi.org/10.3389/fncel.2019.00100

Ejemplares similares

Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism
por: Thakre, Prajwal P., et al.
Publicado: (2017)

Developmental changes in the morphology of mouse hypoglossal motor neurons
por: Kanjhan, Refik, et al.
Publicado: (2015)

Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons
por: Petukhova, Elena, et al.
Publicado: (2018)

The Specification of Glycinergic Neurons and the Role of Glycinergic Transmission in Development
por: Chalphin, Alexander V., et al.
Publicado: (2010)

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy
por: Eichler, Sabrina A, et al.
Publicado: (2008)

Orexin Neurons Receive Glycinergic Innervations
por: Hondo, Mari, et al.
Publicado: (2011)

Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice
por: Guo, Han, et al.
Publicado: (2020)

Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies
por: Zafra, Francisco, et al.
Publicado: (2016)

Circadian Behavioral Responses to Light and Optic Chiasm-Evoked Glutamatergic EPSCs in the Suprachiasmatic Nucleus of ipRGC Conditional vGlut2 Knock-Out Mice
por: Moldavan, Michael G., et al.
Publicado: (2018)

Glycinergic Transmission in the Mammalian Retina
por: Wässle, Heinz, et al.
Publicado: (2009)

Defects of the Glycinergic Synapse in Zebrafish
por: Ogino, Kazutoyo, et al.
Publicado: (2016)

Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens
por: Muñoz, Braulio, et al.
Publicado: (2018)

Data on the recovery of glycinergic neurons after spinal cord injury in lampreys
por: Valle-Maroto, Silvia María, et al.
Publicado: (2020)

Molecular Markers of Mechanosensation in Glycinergic Neurons in the Avian Lumbosacral Spinal Cord
por: Stanchak, Kathryn E., et al.
Publicado: (2022)

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons
por: Ehmsen, Jeffrey T., et al.
Publicado: (2016)

Comparative functional genomics identifies unique molecular features of EPSCs
por: Malik, Vikas, et al.
Publicado: (2022)

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
por: Tian, Yuan, et al.
Publicado: (2014)

Radiation‐induced tongue myokymia with hypoglossal nerve damage, mimicker of motor neuron disease
por: Memon, Anza B., et al.
Publicado: (2017)

Sedative effects of intramuscular alfaxalone administered to cats
por: TAMURA, Jun, et al.
Publicado: (2015)

DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons
por: Bachmann, Sarah, et al.
Publicado: (2021)

Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries Syndrome
por: Aguilan, Jennifer T., et al.
Publicado: (2023)

Muscarinic Modulation of Morphologically Identified Glycinergic Neurons in the Mouse PreBötzinger Complex
por: Zheng, Fang, et al.
Publicado: (2020)

Synaptic Targets of Glycinergic Neurons in Laminae I–III of the Spinal Dorsal Horn
por: Miranda, Camila Oliveira, et al.
Publicado: (2023)

A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons
por: Wiegert, J Simon, et al.
Publicado: (2009)

Coincident glutamatergic depolarizations enhance GABA(A) receptor-dependent Cl(-) influx in mature and suppress Cl(-) efflux in immature neurons
por: Lombardi, Aniello, et al.
Publicado: (2021)

A Strength Endurance Exercise Paradigm Mitigates Deficits in Hypoglossal-Tongue Axis Function, Strength, and Structure in a Rodent Model of Hypoglossal Motor Neuron Degeneration
por: Murphy, Erika R., et al.
Publicado: (2022)

Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction
por: Schneeberger, Marc, et al.
Publicado: (2022)

Long duration anaesthesia in pigs with an infusion of alfaxalone and dexmedetomidine
por: Kat, Irving, et al.
Publicado: (2022)

Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors
por: van der Heijden, Meike E., et al.
Publicado: (2023)

Spike Timing and Reliability in Cortical Pyramidal Neurons: Effects of EPSC Kinetics, Input Synchronization and Background Noise on Spike Timing
por: Rodriguez-Molina, Victor M., et al.
Publicado: (2007)

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit
por: Salmon, Christopher K., et al.
Publicado: (2020)

Protein Expression Landscape Defines the Formation Potential of Mouse Blastoids From EPSCs
por: Min, Zheying, et al.
Publicado: (2022)

Slow glycinergic transmission mediated by transmitter pooling
por: Balakrishnan, Veeramuthu, et al.
Publicado: (2009)

Glycinergic Transmission: Physiological, Developmental and Pathological Implications
por: Harvey, Robert J., et al.
Publicado: (2010)

Glycinergic Synapse Development, Plasticity, and Homeostasis in Zebrafish
por: Ganser, Lisa R., et al.
Publicado: (2009)

Glycinergic Modulation of Pain in Behavioral Animal Models
por: Peiser-Oliver, Julian M., et al.
Publicado: (2022)

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse
por: Chaimowicz, Charlotte, et al.
Publicado: (2019)

Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control
por: Horton, Garret A., et al.
Publicado: (2017)

Intraoperative Monitoring of Hypoglossal Nerve Using Hypoglossal Motor Evoked Potential in Infratentorial Tumor Surgery: A Report of Two Cases
por: Kim, Seung Yeun, et al.
Publicado: (2018)

The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs
por: TAMURA, Jun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uora1v7c87e6vetl6f9cb40ov5