Metformin induces CD11b(+)-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

CD11b(+) myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated anti-tumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We...

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Detalles Bibliográficos
Autores principales: Uehara, Takenori, Eikawa, Shingo, Nishida, Mikako, Kunisada, Yuki, Yoshida, Aki, Fujiwara, Tomohiro, Kunisada, Toshiyuki, Ozaki, Toshifumi, Udono, Heiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440441/
https://www.ncbi.nlm.nih.gov/pubmed/30508092
http://dx.doi.org/10.1093/intimm/dxy079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440441/
https://www.ncbi.nlm.nih.gov/pubmed/30508092
http://dx.doi.org/10.1093/intimm/dxy079

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