Cargando…
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxa...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440584/ https://www.ncbi.nlm.nih.gov/pubmed/30914078 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.12.1900170 |
| _version_ | 1783407414101409792 |
|---|---|
| author | Takashita, Emi Kawakami, Chiharu Ogawa, Rie Morita, Hiroko Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Ota, Akira Togashi, Hayato Saito, Ayako Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato |
| author_facet | Takashita, Emi Kawakami, Chiharu Ogawa, Rie Morita, Hiroko Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Ota, Akira Togashi, Hayato Saito, Ayako Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato |
| author_sort | Takashita, Emi |
| collection | PubMed |
| description | In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans. |
| format | Online Article Text |
| id | pubmed-6440584 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64405842019-08-08 Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 Takashita, Emi Kawakami, Chiharu Ogawa, Rie Morita, Hiroko Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Ota, Akira Togashi, Hayato Saito, Ayako Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato Euro Surveill Rapid Communication In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans. European Centre for Disease Prevention and Control (ECDC) 2019-03-21 /pmc/articles/PMC6440584/ /pubmed/30914078 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.12.1900170 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Takashita, Emi Kawakami, Chiharu Ogawa, Rie Morita, Hiroko Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Ota, Akira Togashi, Hayato Saito, Ayako Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title | Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title_full | Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title_fullStr | Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title_full_unstemmed | Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title_short | Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019 |
| title_sort | influenza a(h3n2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit i38t substitution detected from a hospitalised child without prior baloxavir treatment, japan, january 2019 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440584/ https://www.ncbi.nlm.nih.gov/pubmed/30914078 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.12.1900170 |
| work_keys_str_mv | AT takashitaemi influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT kawakamichiharu influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT ogawarie influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT moritahiroko influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT fujisakiseiichiro influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT shirakuramasayuki influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT miurahideka influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT nakamurakazuya influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT kishidanoriko influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT kuwaharatomoko influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT otaakira influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT togashihayato influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT saitoayako influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT mitamurakeiko influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT abetakashi influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT ichikawamasataka influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT yamazakimasahiko influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT watanabeshinji influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 AT odagiritakato influenzaah3n2virusexhibitingreducedsusceptibilitytobaloxavirduetoapolymeraseacidicsubuniti38tsubstitutiondetectedfromahospitalisedchildwithoutpriorbaloxavirtreatmentjapanjanuary2019 |