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Inverted papilloma of the conjunctiva
OBJECTIVE: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth patte...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440594/ https://www.ncbi.nlm.nih.gov/pubmed/30997398 http://dx.doi.org/10.1136/bmjophth-2018-000193 |
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author | Ramberg, Ingvild Sjö, Nicolai Christian Bonde, Jesper Hansen Heegaard, Steffen |
author_facet | Ramberg, Ingvild Sjö, Nicolai Christian Bonde, Jesper Hansen Heegaard, Steffen |
author_sort | Ramberg, Ingvild |
collection | PubMed |
description | OBJECTIVE: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern. METHODS AND ANALYSIS: Cases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Formalin-fixed and paraffin-embedded tissue was analysed for the presence of HPV by immunohistochemistry, in situ hybridisation (ISH), PCR and HPV typed by sequencing. RESULTS: A total of four cases were retrieved. The age at diagnosis ranged from 41 to 77 years, with an equal sex distribution. All lesions were localised to the bulbar conjunctiva and two of the cases were pigmented. Histopathological examination did not reveal areas of dysplasia. All lesions were p16-positive and p53-positive by immunohistochemistry. High-risk HPV 58 was demonstrated in one lesion by ISH and PCR. CONCLUSION: Here we present four cases of conjunctival inverted papilloma, which is an exceedingly rare tumour with only 11 previously reported cases in the literature. Both clinically and histopathologically, the tumours show distinct features compared with exophytic conjunctival papillomas. Furthermore, this is the first description of high-risk HPV 58 in a conjunctival tumour. The biological behaviour of the tumour is uncertain due to its rareness. However, a complete removal of the lesion and a careful observation are recommended. The finding of HPV 58 underlines the necessity of this precaution. |
format | Online Article Text |
id | pubmed-6440594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-64405942019-04-17 Inverted papilloma of the conjunctiva Ramberg, Ingvild Sjö, Nicolai Christian Bonde, Jesper Hansen Heegaard, Steffen BMJ Open Ophthalmol Original Article OBJECTIVE: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern. METHODS AND ANALYSIS: Cases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Formalin-fixed and paraffin-embedded tissue was analysed for the presence of HPV by immunohistochemistry, in situ hybridisation (ISH), PCR and HPV typed by sequencing. RESULTS: A total of four cases were retrieved. The age at diagnosis ranged from 41 to 77 years, with an equal sex distribution. All lesions were localised to the bulbar conjunctiva and two of the cases were pigmented. Histopathological examination did not reveal areas of dysplasia. All lesions were p16-positive and p53-positive by immunohistochemistry. High-risk HPV 58 was demonstrated in one lesion by ISH and PCR. CONCLUSION: Here we present four cases of conjunctival inverted papilloma, which is an exceedingly rare tumour with only 11 previously reported cases in the literature. Both clinically and histopathologically, the tumours show distinct features compared with exophytic conjunctival papillomas. Furthermore, this is the first description of high-risk HPV 58 in a conjunctival tumour. The biological behaviour of the tumour is uncertain due to its rareness. However, a complete removal of the lesion and a careful observation are recommended. The finding of HPV 58 underlines the necessity of this precaution. BMJ Publishing Group 2019-02-28 /pmc/articles/PMC6440594/ /pubmed/30997398 http://dx.doi.org/10.1136/bmjophth-2018-000193 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Original Article Ramberg, Ingvild Sjö, Nicolai Christian Bonde, Jesper Hansen Heegaard, Steffen Inverted papilloma of the conjunctiva |
title | Inverted papilloma of the conjunctiva |
title_full | Inverted papilloma of the conjunctiva |
title_fullStr | Inverted papilloma of the conjunctiva |
title_full_unstemmed | Inverted papilloma of the conjunctiva |
title_short | Inverted papilloma of the conjunctiva |
title_sort | inverted papilloma of the conjunctiva |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440594/ https://www.ncbi.nlm.nih.gov/pubmed/30997398 http://dx.doi.org/10.1136/bmjophth-2018-000193 |
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