The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies

Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understan...

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Autores principales: Banadyga, Logan, Siragam, Vinayakumar, Zhu, Wenjun, He, Shihua, Cheng, Keding, Qiu, Xiangguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440691/
https://www.ncbi.nlm.nih.gov/pubmed/30949520
http://dx.doi.org/10.1093/ofid/ofz046
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author Banadyga, Logan
Siragam, Vinayakumar
Zhu, Wenjun
He, Shihua
Cheng, Keding
Qiu, Xiangguo
author_facet Banadyga, Logan
Siragam, Vinayakumar
Zhu, Wenjun
He, Shihua
Cheng, Keding
Qiu, Xiangguo
author_sort Banadyga, Logan
collection PubMed
description Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understand the immune response elicited by EVD in the context of treatment with experimental anti-EBOV antibody cocktails, we analyzed 29 cytokines in 42 EBOV-infected rhesus macaques. In comparison to the surviving treated animals, which exhibited minimal aberrations in only a few cytokine levels, nonsurviving animals exhibited a dramatically upregulated inflammatory response that was delayed by antibody treatment.
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spelling pubmed-64406912019-04-04 The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies Banadyga, Logan Siragam, Vinayakumar Zhu, Wenjun He, Shihua Cheng, Keding Qiu, Xiangguo Open Forum Infect Dis Brief Report Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understand the immune response elicited by EVD in the context of treatment with experimental anti-EBOV antibody cocktails, we analyzed 29 cytokines in 42 EBOV-infected rhesus macaques. In comparison to the surviving treated animals, which exhibited minimal aberrations in only a few cytokine levels, nonsurviving animals exhibited a dramatically upregulated inflammatory response that was delayed by antibody treatment. Oxford University Press 2019-02-06 /pmc/articles/PMC6440691/ /pubmed/30949520 http://dx.doi.org/10.1093/ofid/ofz046 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Banadyga, Logan
Siragam, Vinayakumar
Zhu, Wenjun
He, Shihua
Cheng, Keding
Qiu, Xiangguo
The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title_full The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title_fullStr The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title_full_unstemmed The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title_short The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
title_sort cytokine response profile of ebola virus disease in a large cohort of rhesus macaques treated with monoclonal antibodies
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440691/
https://www.ncbi.nlm.nih.gov/pubmed/30949520
http://dx.doi.org/10.1093/ofid/ofz046
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