Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has anticancer properties through EIF4E inhibition, as a...

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Detalles Bibliográficos
Autores principales: Urtishak, Karen A., Wang, Li-San, Culjkovic-Kraljacic, Biljana, Davenport, James W., Porazzi, Patrizia, Vincent, Tiffaney L., Teachey, David T., Tasian, Sarah K., Moore, Jonni S., Seif, Alix E., Jin, Shenghao, Barrett, Jeffrey S., Robinson, Blaine W., Chen, I-Ming L., Harvey, Richard C., Carroll, Martin P., Carroll, Andrew J., Heerema, Nyla A., Devidas, Meenakshi, Dreyer, ZoAnn E., Hilden, Joanne M., Hunger, Stephen P., Willman, Cheryl L., Borden, Katherine L. B., Felix, Carolyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440839/
https://www.ncbi.nlm.nih.gov/pubmed/30478448
http://dx.doi.org/10.1038/s41388-018-0567-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440839/
https://www.ncbi.nlm.nih.gov/pubmed/30478448
http://dx.doi.org/10.1038/s41388-018-0567-7

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