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Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia
The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has anticancer properties through EIF4E inhibition, as a...
Autores principales: | Urtishak, Karen A., Wang, Li-San, Culjkovic-Kraljacic, Biljana, Davenport, James W., Porazzi, Patrizia, Vincent, Tiffaney L., Teachey, David T., Tasian, Sarah K., Moore, Jonni S., Seif, Alix E., Jin, Shenghao, Barrett, Jeffrey S., Robinson, Blaine W., Chen, I-Ming L., Harvey, Richard C., Carroll, Martin P., Carroll, Andrew J., Heerema, Nyla A., Devidas, Meenakshi, Dreyer, ZoAnn E., Hilden, Joanne M., Hunger, Stephen P., Willman, Cheryl L., Borden, Katherine L. B., Felix, Carolyn A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440839/ https://www.ncbi.nlm.nih.gov/pubmed/30478448 http://dx.doi.org/10.1038/s41388-018-0567-7 |
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