Cargando…

Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator

ABSTRACT: For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient numbers of hepatocytes reaching the liver cell pla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Charlotte, Dhawan, Anil, Iansante, Valeria, Filippi, Celine, Mitry, Ragai, Tang, Joanne, Walker, Simon, Fernandez DaCosta, Raquel, Sinha, Siddharth, Hughes, Robin D., Koulmanda, Maria, Fitzpatrick, Emer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440943/ https://www.ncbi.nlm.nih.gov/pubmed/30820592 http://dx.doi.org/10.1007/s00109-019-01747-3

Ejemplares similares

A New High Throughput Screening Platform for Cell Encapsulation in Alginate Hydrogel Shows Improved Hepatocyte Functions by Mesenchymal Stromal Cells Co-encapsulation
por: Iansante, Valeria, et al.
Publicado: (2018)

Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation
por: Jitraruch, Suttiruk, et al.
Publicado: (2017)

Alginate Microencapsulated Hepatocytes Optimised for Transplantation in Acute Liver Failure
por: Jitraruch, Suttiruk, et al.
Publicado: (2014)

Hepatocyte transplantation and advancements in alternative cell sources for liver-based regenerative medicine
por: Lee, Charlotte A, et al.
Publicado: (2018)

Alpha‐1‐antitrypsin in cell and organ transplantation
por: Berger, Mel, et al.
Publicado: (2018)

Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection
por: Wilson, Garrick K., et al.
Publicado: (2015)

Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency
por: Karatas, Esra, et al.
Publicado: (2021)

Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes
por: Qin, Harry H., et al.
Publicado: (2015)

Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)—An open-label, single-arm Simon’s two stage phase 1 study protocol
por: Fitzpatrick, Emer, et al.
Publicado: (2023)

Improvement of hepatocyte engraftment by co‐transplantation with pancreatic islets in hepatocyte transplantation
por: Saitoh, Yoshikatsu, et al.
Publicado: (2021)

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell‐Derived Hepatocytes for Cell‐Based Therapy
por: Blackford, Samuel J.I., et al.
Publicado: (2018)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
por: Kaserman, Joseph E., et al.
Publicado: (2022)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals
por: Dunlea, Danielle M, et al.
Publicado: (2018)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Dysregulated neutrophil function in individuals with alpha-1 antitrypsin deficiency caused by modified membrane cholesterol content.
por: Jundi, Bakr, et al.
Publicado: (2015)

Description of 22 new alpha-1 antitrypsin genetic variants
por: Renoux, Céline, et al.
Publicado: (2018)

Is SARS-COV-2 associated with alpha-1 antitrypsin deficiency?
por: Rodríguez-García, Carlota, et al.
Publicado: (2023)

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals
por: Hawkins, Padraig, et al.
Publicado: (2021)

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes
por: Werder, Rhiannon B., et al.
Publicado: (2021)

Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin
por: Torres-Durán, María, et al.
Publicado: (2023)

Alpha 1-antitrypsin and survival in hepatocellular carcinoma.
por: Tzonou, A., et al.
Publicado: (1990)

alpha1-Antitrypsin deficiency and hepatocellular cancer.
por: Kew, M. C., et al.
Publicado: (1978)

The prevalence of alpha-1 antitrypsin deficiency in Ireland
por: Carroll, Tomás P, et al.
Publicado: (2011)

Alpha 1-antitrypsin retention in an ectopic liver
por: Dettmer, Matthias, et al.
Publicado: (2011)

Polymorphism of alpha-1-antitrypsin in hematological malignancies
por: Topic, Aleksandra, et al.
Publicado: (2009)

Alpha-1-Antitrypsin in Pathogenesis of Hepatocellular Carcinoma
por: Topic, Aleksandra, et al.
Publicado: (2012)

Alpha-1 Antitrypsin Deficiency: The Learning Goes On
por: Stockley, Robert. A.
Publicado: (2020)

Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency
por: Belchamber, Kylie B R, et al.
Publicado: (2020)

Alpha-1 Antitrypsin Deficiency: Home Therapy
por: Annunziata, Anna, et al.
Publicado: (2021)

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients
por: Sark, Annelot D., et al.
Publicado: (2022)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application
por: O’Brien, Michael E., et al.
Publicado: (2022)

Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency
por: Borel, Florie, et al.
Publicado: (2017)

C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency
por: Fee, Laura T., et al.
Publicado: (2021)

Fatty liver disease in children (MAFLD/PeFLD Type 2): unique classification considerations and challenges
por: Hegarty, Robert, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sge07dnhquamf9p1b7v7j4b3b0