Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Group A Streptococcus (GAS) infection is associated with a variety of human diseases. Previous studies indicate GAS infection leads to RAW264.7 cell death, but the mechanism is unclear. Here, analyzing the timing of reactive oxygen species (ROS) production and using mitochondrial ROS scavenger, we f...

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Detalles Bibliográficos
Autores principales: Tsao, Nina, Kuo, Chih-Feng, Cheng, Miao-Hui, Lin, Wei-Chen, Lin, Chiou-Feng, Lin, Yee-Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440947/
https://www.ncbi.nlm.nih.gov/pubmed/30926881
http://dx.doi.org/10.1038/s41598-019-41853-3

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