Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP

Cleavage of the amyloid precursor protein’s (APP) transmembrane domain (TMD) by γ-secretase is a crucial step in the aetiology of Alzheimer’s Disease (AD). Mutations in the APP TMD alter cleavage and lead to familial forms of AD (FAD). The majority of FAD mutations shift the preference of initial cl...

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Detalles Bibliográficos
Autores principales: Götz, Alexander, Högel, Philipp, Silber, Mara, Chaitoglou, Iro, Luy, Burkhard, Muhle-Goll, Claudia, Scharnagl, Christina, Langosch, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440955/
https://www.ncbi.nlm.nih.gov/pubmed/30926830
http://dx.doi.org/10.1038/s41598-019-41766-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440955/
https://www.ncbi.nlm.nih.gov/pubmed/30926830
http://dx.doi.org/10.1038/s41598-019-41766-1

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