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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contrib...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440956/ https://www.ncbi.nlm.nih.gov/pubmed/30926794 http://dx.doi.org/10.1038/s41467-019-08578-3 |
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| author | López, Cristina Kleinheinz, Kortine Aukema, Sietse M. Rohde, Marius Bernhart, Stephan H. Hübschmann, Daniel Wagener, Rabea Toprak, Umut H. Raimondi, Francesco Kreuz, Markus Waszak, Sebastian M. Huang, Zhiqin Sieverling, Lina Paramasivam, Nagarajan Seufert, Julian Sungalee, Stephanie Russell, Robert B. Bausinger, Julia Kretzmer, Helene Ammerpohl, Ole Bergmann, Anke K. Binder, Hans Borkhardt, Arndt Brors, Benedikt Claviez, Alexander Doose, Gero Feuerbach, Lars Haake, Andrea Hansmann, Martin-Leo Hoell, Jessica Hummel, Michael Korbel, Jan O. Lawerenz, Chris Lenze, Dido Radlwimmer, Bernhard Richter, Julia Rosenstiel, Philip Rosenwald, Andreas Schilhabel, Markus B. Stein, Harald Stilgenbauer, Stephan Stadler, Peter F. Szczepanowski, Monika Weniger, Marc A. Zapatka, Marc Eils, Roland Lichter, Peter Loeffler, Markus Möller, Peter Trümper, Lorenz Klapper, Wolfram Hoffmann, Steve Küppers, Ralf Burkhardt, Birgit Schlesner, Matthias Siebert, Reiner |
| author_facet | López, Cristina Kleinheinz, Kortine Aukema, Sietse M. Rohde, Marius Bernhart, Stephan H. Hübschmann, Daniel Wagener, Rabea Toprak, Umut H. Raimondi, Francesco Kreuz, Markus Waszak, Sebastian M. Huang, Zhiqin Sieverling, Lina Paramasivam, Nagarajan Seufert, Julian Sungalee, Stephanie Russell, Robert B. Bausinger, Julia Kretzmer, Helene Ammerpohl, Ole Bergmann, Anke K. Binder, Hans Borkhardt, Arndt Brors, Benedikt Claviez, Alexander Doose, Gero Feuerbach, Lars Haake, Andrea Hansmann, Martin-Leo Hoell, Jessica Hummel, Michael Korbel, Jan O. Lawerenz, Chris Lenze, Dido Radlwimmer, Bernhard Richter, Julia Rosenstiel, Philip Rosenwald, Andreas Schilhabel, Markus B. Stein, Harald Stilgenbauer, Stephan Stadler, Peter F. Szczepanowski, Monika Weniger, Marc A. Zapatka, Marc Eils, Roland Lichter, Peter Loeffler, Markus Möller, Peter Trümper, Lorenz Klapper, Wolfram Hoffmann, Steve Küppers, Ralf Burkhardt, Birgit Schlesner, Matthias Siebert, Reiner |
| author_sort | López, Cristina |
| collection | PubMed |
| description | Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing. |
| format | Online Article Text |
| id | pubmed-6440956 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64409562019-04-01 Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma López, Cristina Kleinheinz, Kortine Aukema, Sietse M. Rohde, Marius Bernhart, Stephan H. Hübschmann, Daniel Wagener, Rabea Toprak, Umut H. Raimondi, Francesco Kreuz, Markus Waszak, Sebastian M. Huang, Zhiqin Sieverling, Lina Paramasivam, Nagarajan Seufert, Julian Sungalee, Stephanie Russell, Robert B. Bausinger, Julia Kretzmer, Helene Ammerpohl, Ole Bergmann, Anke K. Binder, Hans Borkhardt, Arndt Brors, Benedikt Claviez, Alexander Doose, Gero Feuerbach, Lars Haake, Andrea Hansmann, Martin-Leo Hoell, Jessica Hummel, Michael Korbel, Jan O. Lawerenz, Chris Lenze, Dido Radlwimmer, Bernhard Richter, Julia Rosenstiel, Philip Rosenwald, Andreas Schilhabel, Markus B. Stein, Harald Stilgenbauer, Stephan Stadler, Peter F. Szczepanowski, Monika Weniger, Marc A. Zapatka, Marc Eils, Roland Lichter, Peter Loeffler, Markus Möller, Peter Trümper, Lorenz Klapper, Wolfram Hoffmann, Steve Küppers, Ralf Burkhardt, Birgit Schlesner, Matthias Siebert, Reiner Nat Commun Article Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing. Nature Publishing Group UK 2019-03-29 /pmc/articles/PMC6440956/ /pubmed/30926794 http://dx.doi.org/10.1038/s41467-019-08578-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article López, Cristina Kleinheinz, Kortine Aukema, Sietse M. Rohde, Marius Bernhart, Stephan H. Hübschmann, Daniel Wagener, Rabea Toprak, Umut H. Raimondi, Francesco Kreuz, Markus Waszak, Sebastian M. Huang, Zhiqin Sieverling, Lina Paramasivam, Nagarajan Seufert, Julian Sungalee, Stephanie Russell, Robert B. Bausinger, Julia Kretzmer, Helene Ammerpohl, Ole Bergmann, Anke K. Binder, Hans Borkhardt, Arndt Brors, Benedikt Claviez, Alexander Doose, Gero Feuerbach, Lars Haake, Andrea Hansmann, Martin-Leo Hoell, Jessica Hummel, Michael Korbel, Jan O. Lawerenz, Chris Lenze, Dido Radlwimmer, Bernhard Richter, Julia Rosenstiel, Philip Rosenwald, Andreas Schilhabel, Markus B. Stein, Harald Stilgenbauer, Stephan Stadler, Peter F. Szczepanowski, Monika Weniger, Marc A. Zapatka, Marc Eils, Roland Lichter, Peter Loeffler, Markus Möller, Peter Trümper, Lorenz Klapper, Wolfram Hoffmann, Steve Küppers, Ralf Burkhardt, Birgit Schlesner, Matthias Siebert, Reiner Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title | Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_full | Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_fullStr | Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_full_unstemmed | Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_short | Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_sort | genomic and transcriptomic changes complement each other in the pathogenesis of sporadic burkitt lymphoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440956/ https://www.ncbi.nlm.nih.gov/pubmed/30926794 http://dx.doi.org/10.1038/s41467-019-08578-3 |
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