Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Exposure of articular cartilage to excessive mechanical loading is deeply involved in the pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading-inducible factor in chondrocytes, detected at high levels in middle and deep layers of cartilage after cyclic strain or hydros...

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Detalles Bibliográficos
Autores principales: Chang, Song Ho, Mori, Daisuke, Kobayashi, Hiroshi, Mori, Yoshifumi, Nakamoto, Hideki, Okada, Keita, Taniguchi, Yuki, Sugita, Shurei, Yano, Fumiko, Chung, Ung-il, Kim-Kaneyama, Joo-ri, Yanagita, Motoko, Economides, Aris, Canalis, Ernesto, Chen, Di, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441020/
https://www.ncbi.nlm.nih.gov/pubmed/30926814
http://dx.doi.org/10.1038/s41467-019-09491-5

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