A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in the course of backcrossing to the FVB/N background. Microsatellite analyses indicate that this cancer phenotype is linked to a 20 Mb region of 129P2 ch...

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Detalles Bibliográficos
Autores principales: Krimpenfort, Paul, Snoek, Margriet, Lambooij, Jan-Paul, Song, Ji-Ying, van der Weide, Robin, Bhaskaran, Rajith, Teunissen, Hans, Adams, David J., de Wit, Elzo, Berns, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441055/
https://www.ncbi.nlm.nih.gov/pubmed/30926782
http://dx.doi.org/10.1038/s41467-019-09321-8

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