Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK lineage, that NK cell development and responsiveness ar...

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Detalles Bibliográficos
Autores principales: Niogret, Charlène, Miah, S. M. Shahjahan, Rota, Giorgia, Fonta, Nicolas P., Wang, Haiping, Held, Werner, Birchmeier, Walter, Sexl, Veronica, Yang, Wentian, Vivier, Eric, Ho, Ping-Chih, Brossay, Laurent, Guarda, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441079/
https://www.ncbi.nlm.nih.gov/pubmed/30926899
http://dx.doi.org/10.1038/s41467-019-09431-3

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