Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness potential, but whether they impact the immune microenvironment is unknown. Here we show that LUAD cells use paracrine Wnt1 signaling to induce immune resistance. In TCGA, Wnt1 correlates strongly with tolerogenic gen...

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Detalles Bibliográficos
Autores principales: Kerdidani, Dimitra, Chouvardas, Panagiotis, Arjo, Ares Rocanin, Giopanou, Ioanna, Ntaliarda, Giannoula, Guo, Yu Amanda, Tsikitis, Mary, Kazamias, Georgios, Potaris, Konstantinos, Stathopoulos, Georgios T., Zakynthinos, Spyros, Kalomenidis, Ioannis, Soumelis, Vassili, Kollias, George, Tsoumakidou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441097/
https://www.ncbi.nlm.nih.gov/pubmed/30926812
http://dx.doi.org/10.1038/s41467-019-09370-z

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