Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries: A Cohort and Nested Case–Control Study Using Automated Health Data Sources

BACKGROUND: Agomelatine is a melatonin receptor agonist and serotonin 5-HT(2C) receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. Hepatotoxic reactions have been repo...

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Detalles Bibliográficos
Autores principales: Pladevall-Vila, Manel, Pottegård, Anton, Schink, Tania, Reutfors, Johan, Morros, Rosa, Poblador-Plou, Beatriz, Timmer, Antje, Forns, Joan, Hellfritzsch, Maja, Reinders, Tammo, Hägg, David, Giner-Soriano, Maria, Prados-Torres, Alexandra, Cainzos-Achirica, Miguel, Hallas, Jesper, Brandt, Lena, Cortés, Jordi, Aguado, Jaume, Perlemuter, Gabriel, Falissard, Bruno, Castellsagué, Jordi, Jacquot, Emmanuelle, Deltour, Nicolas, Perez-Gutthann, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441103/
https://www.ncbi.nlm.nih.gov/pubmed/30830574
http://dx.doi.org/10.1007/s40263-019-00611-9

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