Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether cancer-initiating cells (C-ICs) have similar epige...

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Detalles Bibliográficos
Autores principales: Lima-Fernandes, Evelyne, Murison, Alex, da Silva Medina, Tiago, Wang, Yadong, Ma, Anqi, Leung, Cherry, Luciani, Genna M., Haynes, Jennifer, Pollett, Aaron, Zeller, Constanze, Duan, Shili, Kreso, Antonija, Barsyte-Lovejoy, Dalia, Wouters, Bradly G., Jin, Jian, Carvalho, Daniel D. De, Lupien, Mathieu, Arrowsmith, Cheryl H., O’Brien, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441108/
https://www.ncbi.nlm.nih.gov/pubmed/30926792
http://dx.doi.org/10.1038/s41467-019-09309-4

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