Mechanisms associated with biogenesis of exosomes in cancer

Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain...

Descripción completa

Detalles Bibliográficos
Autores principales: McAndrews, Kathleen M., Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441149/
https://www.ncbi.nlm.nih.gov/pubmed/30925917
http://dx.doi.org/10.1186/s12943-019-0963-9
_version_ 1783407502707130368
author McAndrews, Kathleen M.
Kalluri, Raghu
author_facet McAndrews, Kathleen M.
Kalluri, Raghu
author_sort McAndrews, Kathleen M.
collection PubMed
description Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.
format Online
Article
Text
id pubmed-6441149
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-64411492019-04-11 Mechanisms associated with biogenesis of exosomes in cancer McAndrews, Kathleen M. Kalluri, Raghu Mol Cancer Review Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer. BioMed Central 2019-03-30 /pmc/articles/PMC6441149/ /pubmed/30925917 http://dx.doi.org/10.1186/s12943-019-0963-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
McAndrews, Kathleen M.
Kalluri, Raghu
Mechanisms associated with biogenesis of exosomes in cancer
title Mechanisms associated with biogenesis of exosomes in cancer
title_full Mechanisms associated with biogenesis of exosomes in cancer
title_fullStr Mechanisms associated with biogenesis of exosomes in cancer
title_full_unstemmed Mechanisms associated with biogenesis of exosomes in cancer
title_short Mechanisms associated with biogenesis of exosomes in cancer
title_sort mechanisms associated with biogenesis of exosomes in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441149/
https://www.ncbi.nlm.nih.gov/pubmed/30925917
http://dx.doi.org/10.1186/s12943-019-0963-9
work_keys_str_mv AT mcandrewskathleenm mechanismsassociatedwithbiogenesisofexosomesincancer
AT kalluriraghu mechanismsassociatedwithbiogenesisofexosomesincancer

Ejemplares similares