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The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy
Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids such as plasma, saliva, breast milk, cerebr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441168/ https://www.ncbi.nlm.nih.gov/pubmed/30925929 http://dx.doi.org/10.1186/s12943-019-0967-5 |
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author | Huang, Tingting Song, Chunli Zheng, Lei Xia, Ligang Li, Yang Zhou, Yiwen |
author_facet | Huang, Tingting Song, Chunli Zheng, Lei Xia, Ligang Li, Yang Zhou, Yiwen |
author_sort | Huang, Tingting |
collection | PubMed |
description | Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids such as plasma, saliva, breast milk, cerebrospinal fluid, semen, urine, lymphatic fluid, amniotic fluid, sputum and synovial fluid. EVs deliver almost all types of biomolecules such as proteins, nucleic acids, metabolites, and even pharmacological compounds. These bioactive molecules can be delivered to recipient cells to influence their biological properties, modify surrounding microenvironment and distant targets. The extensive exploration of EVs enhances our comprehension of GC biology referring to tumor growth, metastasis, immune response and evasion, chemoresistance and treatment. In this review, we will sum up the effects of GC-derived EVs to the tumor microenvironment. Moreover, we will also summarize the function of microenvironment-derived EVs in GC and discuss how the bidirectional communication between tumor and microenvironment affect GC growth, metastatic behavior, immune response, and drug resistance. At last, we prospect the clinical application viewpoint of EVs in GC. |
format | Online Article Text |
id | pubmed-6441168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64411682019-04-11 The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy Huang, Tingting Song, Chunli Zheng, Lei Xia, Ligang Li, Yang Zhou, Yiwen Mol Cancer Review Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids such as plasma, saliva, breast milk, cerebrospinal fluid, semen, urine, lymphatic fluid, amniotic fluid, sputum and synovial fluid. EVs deliver almost all types of biomolecules such as proteins, nucleic acids, metabolites, and even pharmacological compounds. These bioactive molecules can be delivered to recipient cells to influence their biological properties, modify surrounding microenvironment and distant targets. The extensive exploration of EVs enhances our comprehension of GC biology referring to tumor growth, metastasis, immune response and evasion, chemoresistance and treatment. In this review, we will sum up the effects of GC-derived EVs to the tumor microenvironment. Moreover, we will also summarize the function of microenvironment-derived EVs in GC and discuss how the bidirectional communication between tumor and microenvironment affect GC growth, metastatic behavior, immune response, and drug resistance. At last, we prospect the clinical application viewpoint of EVs in GC. BioMed Central 2019-03-30 /pmc/articles/PMC6441168/ /pubmed/30925929 http://dx.doi.org/10.1186/s12943-019-0967-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Huang, Tingting Song, Chunli Zheng, Lei Xia, Ligang Li, Yang Zhou, Yiwen The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title | The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title_full | The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title_fullStr | The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title_full_unstemmed | The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title_short | The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
title_sort | roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441168/ https://www.ncbi.nlm.nih.gov/pubmed/30925929 http://dx.doi.org/10.1186/s12943-019-0967-5 |
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