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Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells

BACKGROUND: The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC). METHODS: Cortactin and phosphorylated co...

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Detalles Bibliográficos
Autores principales:	Stock, Katharina, Borrink, Rebekka, Mikesch, Jan-Henrik, Hansmeier, Anna, Rehkämper, Jan, Trautmann, Marcel, Wardelmann, Eva, Hartmann, Wolfgang, Sperveslage, Jan, Steinestel, Konrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441202/ https://www.ncbi.nlm.nih.gov/pubmed/30976201 http://dx.doi.org/10.1186/s12935-019-0798-x

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