Cargando…
Ferroptosis, a new form of cell death: opportunities and challenges in cancer
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the c...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/ https://www.ncbi.nlm.nih.gov/pubmed/30925886 http://dx.doi.org/10.1186/s13045-019-0720-y |
_version_ | 1783407516113174528 |
---|---|
author | Mou, Yanhua Wang, Jun Wu, Jinchun He, Dan Zhang, Chunfang Duan, Chaojun Li, Bin |
author_facet | Mou, Yanhua Wang, Jun Wu, Jinchun He, Dan Zhang, Chunfang Duan, Chaojun Li, Bin |
author_sort | Mou, Yanhua |
collection | PubMed |
description | Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some “conventional” drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment. |
format | Online Article Text |
id | pubmed-6441206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64412062019-04-11 Ferroptosis, a new form of cell death: opportunities and challenges in cancer Mou, Yanhua Wang, Jun Wu, Jinchun He, Dan Zhang, Chunfang Duan, Chaojun Li, Bin J Hematol Oncol Review Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some “conventional” drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment. BioMed Central 2019-03-29 /pmc/articles/PMC6441206/ /pubmed/30925886 http://dx.doi.org/10.1186/s13045-019-0720-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Mou, Yanhua Wang, Jun Wu, Jinchun He, Dan Zhang, Chunfang Duan, Chaojun Li, Bin Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title | Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title_full | Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title_fullStr | Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title_full_unstemmed | Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title_short | Ferroptosis, a new form of cell death: opportunities and challenges in cancer |
title_sort | ferroptosis, a new form of cell death: opportunities and challenges in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/ https://www.ncbi.nlm.nih.gov/pubmed/30925886 http://dx.doi.org/10.1186/s13045-019-0720-y |
work_keys_str_mv | AT mouyanhua ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT wangjun ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT wujinchun ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT hedan ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT zhangchunfang ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT duanchaojun ferroptosisanewformofcelldeathopportunitiesandchallengesincancer AT libin ferroptosisanewformofcelldeathopportunitiesandchallengesincancer |