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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the c...

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Autores principales: Mou, Yanhua, Wang, Jun, Wu, Jinchun, He, Dan, Zhang, Chunfang, Duan, Chaojun, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/
https://www.ncbi.nlm.nih.gov/pubmed/30925886
http://dx.doi.org/10.1186/s13045-019-0720-y
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author Mou, Yanhua
Wang, Jun
Wu, Jinchun
He, Dan
Zhang, Chunfang
Duan, Chaojun
Li, Bin
author_facet Mou, Yanhua
Wang, Jun
Wu, Jinchun
He, Dan
Zhang, Chunfang
Duan, Chaojun
Li, Bin
author_sort Mou, Yanhua
collection PubMed
description Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some “conventional” drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment.
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spelling pubmed-64412062019-04-11 Ferroptosis, a new form of cell death: opportunities and challenges in cancer Mou, Yanhua Wang, Jun Wu, Jinchun He, Dan Zhang, Chunfang Duan, Chaojun Li, Bin J Hematol Oncol Review Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some “conventional” drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment. BioMed Central 2019-03-29 /pmc/articles/PMC6441206/ /pubmed/30925886 http://dx.doi.org/10.1186/s13045-019-0720-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mou, Yanhua
Wang, Jun
Wu, Jinchun
He, Dan
Zhang, Chunfang
Duan, Chaojun
Li, Bin
Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title_full Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title_fullStr Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title_full_unstemmed Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title_short Ferroptosis, a new form of cell death: opportunities and challenges in cancer
title_sort ferroptosis, a new form of cell death: opportunities and challenges in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/
https://www.ncbi.nlm.nih.gov/pubmed/30925886
http://dx.doi.org/10.1186/s13045-019-0720-y
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