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Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Genome-wide association studies (GWAS) have identified genetic variants at 34 loci contributing to age-related macular degeneration (AMD)(1–3). We generated transcriptional profiles of postmortem retina from 453 controls and cases at distinct stages of AMD and integrated retinal transcriptomes, cove...

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Detalles Bibliográficos
Autores principales:	Ratnapriya, Rinki, Sosina, Olukayode A., Starostik, Margaret R., Kwicklis, Madeline, Kapphahn, Rebecca J., Fritsche, Lars G., Walton, Ashley, Arvanitis, Marios, Gieser, Linn, Pietraszkiewicz, Alexandra, Montezuma, Sandra R., Chew, Emily Y., Battle, Alexis, Abecasis, Gonçalo R., Ferrington, Deborah A., Chatterjee, Nilanjan, Swaroop, Anand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441365/ https://www.ncbi.nlm.nih.gov/pubmed/30742112 http://dx.doi.org/10.1038/s41588-019-0351-9

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