Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements

Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed ‘CEN-SELECT’, to systematically interrogate the structural landscape...

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Detalles Bibliográficos
Autores principales: Ly, Peter, Brunner, Simon F., Shoshani, Ofer, Kim, Dong Hyun, Lan, Weijie, Pyntikova, Tatyana, Flanagan, Adrienne M., Behjati, Sam, Page, David C., Campbell, Peter J., Cleveland, Don W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441390/
https://www.ncbi.nlm.nih.gov/pubmed/30833795
http://dx.doi.org/10.1038/s41588-019-0360-8

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