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Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue

The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great im...

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Autores principales: Ayers, Duncan, Boughanem, Hatim, Macías-González, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533/
https://www.ncbi.nlm.nih.gov/pubmed/31007685
http://dx.doi.org/10.1155/2019/7406078
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author Ayers, Duncan
Boughanem, Hatim
Macías-González, Manuel
author_facet Ayers, Duncan
Boughanem, Hatim
Macías-González, Manuel
author_sort Ayers, Duncan
collection PubMed
description The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. There is a large evidence, both in epidemiological studies in humans and in animal models, of the association between obesity and an increased risk of cancer incidence. In the last years, the initial discovery of epigenetic mechanisms represents the most relevant finding to explain how the genome interacts with environmental factors and the ripple effects on disease pathogeneses. Since then, all epigenetic process has been investigated by the scientific communities for nearly two decades to determine which components are involved in this process. DNA/RNA methylation and miRNA are classified as two of the most important representative classes of such epigenetic mechanisms and dysregulated activity of such mechanism can certainly contribute to disease pathogenesis and/or progression especially in tumors. This review article serves to highlight the impact of DNA/RNA methylation and miRNA-based epigenetic mechanism activities in the interplay between obesity and the development and clinical significance of colorectal cancer.
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spelling pubmed-64415332019-04-21 Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue Ayers, Duncan Boughanem, Hatim Macías-González, Manuel J Oncol Review Article The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. There is a large evidence, both in epidemiological studies in humans and in animal models, of the association between obesity and an increased risk of cancer incidence. In the last years, the initial discovery of epigenetic mechanisms represents the most relevant finding to explain how the genome interacts with environmental factors and the ripple effects on disease pathogeneses. Since then, all epigenetic process has been investigated by the scientific communities for nearly two decades to determine which components are involved in this process. DNA/RNA methylation and miRNA are classified as two of the most important representative classes of such epigenetic mechanisms and dysregulated activity of such mechanism can certainly contribute to disease pathogenesis and/or progression especially in tumors. This review article serves to highlight the impact of DNA/RNA methylation and miRNA-based epigenetic mechanism activities in the interplay between obesity and the development and clinical significance of colorectal cancer. Hindawi 2019-03-17 /pmc/articles/PMC6441533/ /pubmed/31007685 http://dx.doi.org/10.1155/2019/7406078 Text en Copyright © 2019 Duncan Ayers et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ayers, Duncan
Boughanem, Hatim
Macías-González, Manuel
Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title_full Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title_fullStr Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title_full_unstemmed Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title_short Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
title_sort epigenetic influences in the obesity/colorectal cancer axis: a novel theragnostic avenue
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533/
https://www.ncbi.nlm.nih.gov/pubmed/31007685
http://dx.doi.org/10.1155/2019/7406078
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