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Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue
The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great im...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533/ https://www.ncbi.nlm.nih.gov/pubmed/31007685 http://dx.doi.org/10.1155/2019/7406078 |
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author | Ayers, Duncan Boughanem, Hatim Macías-González, Manuel |
author_facet | Ayers, Duncan Boughanem, Hatim Macías-González, Manuel |
author_sort | Ayers, Duncan |
collection | PubMed |
description | The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. There is a large evidence, both in epidemiological studies in humans and in animal models, of the association between obesity and an increased risk of cancer incidence. In the last years, the initial discovery of epigenetic mechanisms represents the most relevant finding to explain how the genome interacts with environmental factors and the ripple effects on disease pathogeneses. Since then, all epigenetic process has been investigated by the scientific communities for nearly two decades to determine which components are involved in this process. DNA/RNA methylation and miRNA are classified as two of the most important representative classes of such epigenetic mechanisms and dysregulated activity of such mechanism can certainly contribute to disease pathogenesis and/or progression especially in tumors. This review article serves to highlight the impact of DNA/RNA methylation and miRNA-based epigenetic mechanism activities in the interplay between obesity and the development and clinical significance of colorectal cancer. |
format | Online Article Text |
id | pubmed-6441533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64415332019-04-21 Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue Ayers, Duncan Boughanem, Hatim Macías-González, Manuel J Oncol Review Article The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. There is a large evidence, both in epidemiological studies in humans and in animal models, of the association between obesity and an increased risk of cancer incidence. In the last years, the initial discovery of epigenetic mechanisms represents the most relevant finding to explain how the genome interacts with environmental factors and the ripple effects on disease pathogeneses. Since then, all epigenetic process has been investigated by the scientific communities for nearly two decades to determine which components are involved in this process. DNA/RNA methylation and miRNA are classified as two of the most important representative classes of such epigenetic mechanisms and dysregulated activity of such mechanism can certainly contribute to disease pathogenesis and/or progression especially in tumors. This review article serves to highlight the impact of DNA/RNA methylation and miRNA-based epigenetic mechanism activities in the interplay between obesity and the development and clinical significance of colorectal cancer. Hindawi 2019-03-17 /pmc/articles/PMC6441533/ /pubmed/31007685 http://dx.doi.org/10.1155/2019/7406078 Text en Copyright © 2019 Duncan Ayers et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ayers, Duncan Boughanem, Hatim Macías-González, Manuel Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title | Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title_full | Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title_fullStr | Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title_full_unstemmed | Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title_short | Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue |
title_sort | epigenetic influences in the obesity/colorectal cancer axis: a novel theragnostic avenue |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533/ https://www.ncbi.nlm.nih.gov/pubmed/31007685 http://dx.doi.org/10.1155/2019/7406078 |
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