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A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441588/ https://www.ncbi.nlm.nih.gov/pubmed/30349105 http://dx.doi.org/10.1038/s41593-018-0251-9 |
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author | Mátyás, Ferenc Komlósi, Gergely Babiczky, Ákos Kocsis, Kinga Barthó, Péter Barsy, Boglárka Dávid, Csaba Kanti, Vivien Porrero, Cesar Magyar, Aletta Szűcs, Iván Clasca, Francisco Acsády, László |
author_facet | Mátyás, Ferenc Komlósi, Gergely Babiczky, Ákos Kocsis, Kinga Barthó, Péter Barsy, Boglárka Dávid, Csaba Kanti, Vivien Porrero, Cesar Magyar, Aletta Szűcs, Iván Clasca, Francisco Acsády, László |
author_sort | Mátyás, Ferenc |
collection | PubMed |
description | Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells could elicit active locomotion lasting for minutes, stereotyped microarousals or transient disruption of sleep rhythms depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and REM sleep. The DMT/CR+ cells displayed elevated activity prior to arousal, received selective subcortical inputs and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal. |
format | Online Article Text |
id | pubmed-6441588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-64415882019-04-22 A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain Mátyás, Ferenc Komlósi, Gergely Babiczky, Ákos Kocsis, Kinga Barthó, Péter Barsy, Boglárka Dávid, Csaba Kanti, Vivien Porrero, Cesar Magyar, Aletta Szűcs, Iván Clasca, Francisco Acsády, László Nat Neurosci Article Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells could elicit active locomotion lasting for minutes, stereotyped microarousals or transient disruption of sleep rhythms depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and REM sleep. The DMT/CR+ cells displayed elevated activity prior to arousal, received selective subcortical inputs and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal. 2018-10-22 2018-11 /pmc/articles/PMC6441588/ /pubmed/30349105 http://dx.doi.org/10.1038/s41593-018-0251-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Mátyás, Ferenc Komlósi, Gergely Babiczky, Ákos Kocsis, Kinga Barthó, Péter Barsy, Boglárka Dávid, Csaba Kanti, Vivien Porrero, Cesar Magyar, Aletta Szűcs, Iván Clasca, Francisco Acsády, László A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain |
title | A highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
title_full | A highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
title_fullStr | A highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
title_full_unstemmed | A highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
title_short | A highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
title_sort | highly collateralized thalamic cell type with arousal predicting
activity serves as a key hub for graded state transitions in the
forebrain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441588/ https://www.ncbi.nlm.nih.gov/pubmed/30349105 http://dx.doi.org/10.1038/s41593-018-0251-9 |
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