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A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain

Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that...

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Autores principales: Mátyás, Ferenc, Komlósi, Gergely, Babiczky, Ákos, Kocsis, Kinga, Barthó, Péter, Barsy, Boglárka, Dávid, Csaba, Kanti, Vivien, Porrero, Cesar, Magyar, Aletta, Szűcs, Iván, Clasca, Francisco, Acsády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441588/
https://www.ncbi.nlm.nih.gov/pubmed/30349105
http://dx.doi.org/10.1038/s41593-018-0251-9
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author Mátyás, Ferenc
Komlósi, Gergely
Babiczky, Ákos
Kocsis, Kinga
Barthó, Péter
Barsy, Boglárka
Dávid, Csaba
Kanti, Vivien
Porrero, Cesar
Magyar, Aletta
Szűcs, Iván
Clasca, Francisco
Acsády, László
author_facet Mátyás, Ferenc
Komlósi, Gergely
Babiczky, Ákos
Kocsis, Kinga
Barthó, Péter
Barsy, Boglárka
Dávid, Csaba
Kanti, Vivien
Porrero, Cesar
Magyar, Aletta
Szűcs, Iván
Clasca, Francisco
Acsády, László
author_sort Mátyás, Ferenc
collection PubMed
description Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells could elicit active locomotion lasting for minutes, stereotyped microarousals or transient disruption of sleep rhythms depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and REM sleep. The DMT/CR+ cells displayed elevated activity prior to arousal, received selective subcortical inputs and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal.
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spelling pubmed-64415882019-04-22 A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain Mátyás, Ferenc Komlósi, Gergely Babiczky, Ákos Kocsis, Kinga Barthó, Péter Barsy, Boglárka Dávid, Csaba Kanti, Vivien Porrero, Cesar Magyar, Aletta Szűcs, Iván Clasca, Francisco Acsády, László Nat Neurosci Article Sleep cycles consist of rapid alterations between arousal states including transient perturbation of sleep rhythms, microarousals and full-blown awake states. Here we demonstrate that the calretinin containing (CR+) neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells could elicit active locomotion lasting for minutes, stereotyped microarousals or transient disruption of sleep rhythms depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and REM sleep. The DMT/CR+ cells displayed elevated activity prior to arousal, received selective subcortical inputs and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal. 2018-10-22 2018-11 /pmc/articles/PMC6441588/ /pubmed/30349105 http://dx.doi.org/10.1038/s41593-018-0251-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mátyás, Ferenc
Komlósi, Gergely
Babiczky, Ákos
Kocsis, Kinga
Barthó, Péter
Barsy, Boglárka
Dávid, Csaba
Kanti, Vivien
Porrero, Cesar
Magyar, Aletta
Szűcs, Iván
Clasca, Francisco
Acsády, László
A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title_full A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title_fullStr A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title_full_unstemmed A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title_short A highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
title_sort highly collateralized thalamic cell type with arousal predicting activity serves as a key hub for graded state transitions in the forebrain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441588/
https://www.ncbi.nlm.nih.gov/pubmed/30349105
http://dx.doi.org/10.1038/s41593-018-0251-9
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