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Mechanisms of Hepatic Cholestatic Drug Injury
Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to ad...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
XIA & HE Publishing Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441637/ https://www.ncbi.nlm.nih.gov/pubmed/30944824 http://dx.doi.org/10.14218/JCTH.2018.00042 |
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author | Kolarić, Tea Omanović Ninčević, Vjera Smolić, Robert Smolić, Martina Wu, George Y |
author_facet | Kolarić, Tea Omanović Ninčević, Vjera Smolić, Robert Smolić, Martina Wu, George Y |
author_sort | Kolarić, Tea Omanović |
collection | PubMed |
description | Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes. |
format | Online Article Text |
id | pubmed-6441637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | XIA & HE Publishing Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64416372019-04-03 Mechanisms of Hepatic Cholestatic Drug Injury Kolarić, Tea Omanović Ninčević, Vjera Smolić, Robert Smolić, Martina Wu, George Y J Clin Transl Hepatol Review Article Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes. XIA & HE Publishing Inc. 2019-03-25 2019-03-28 /pmc/articles/PMC6441637/ /pubmed/30944824 http://dx.doi.org/10.14218/JCTH.2018.00042 Text en © 2019 Authors. http://creativecommons.org/licenses/by-nc/4.0/ This article has been published under the terms of Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which permits noncommercial unrestricted use, distribution, and reproduction in any medium, provided that the following statement is provided. “This article has been published in Journal of Clinical and Translational Hepatology at DOI: 10.14218/JCTH.2018.00042 and can also be viewed on the Journal’s website at http://www.jcthnet.com”. |
spellingShingle | Review Article Kolarić, Tea Omanović Ninčević, Vjera Smolić, Robert Smolić, Martina Wu, George Y Mechanisms of Hepatic Cholestatic Drug Injury |
title | Mechanisms of Hepatic Cholestatic Drug Injury |
title_full | Mechanisms of Hepatic Cholestatic Drug Injury |
title_fullStr | Mechanisms of Hepatic Cholestatic Drug Injury |
title_full_unstemmed | Mechanisms of Hepatic Cholestatic Drug Injury |
title_short | Mechanisms of Hepatic Cholestatic Drug Injury |
title_sort | mechanisms of hepatic cholestatic drug injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441637/ https://www.ncbi.nlm.nih.gov/pubmed/30944824 http://dx.doi.org/10.14218/JCTH.2018.00042 |
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