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Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry

Peak oxygen uptake (V′(O(2)peak)) is recognised as the best expression of aerobic fitness. Therefore, it is essential that V′(O(2)peak) reference values are accurate for interpreting a cardiopulmonary exercise test (CPET). These values are country specific and influenced by underlying biological age...

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Autores principales: Mylius, Caspar Frederik, Krijnen, Wilhelmus Petrus, van der Schans, Cornelis Peter, Takken, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441675/
https://www.ncbi.nlm.nih.gov/pubmed/30949491
http://dx.doi.org/10.1183/23120541.00056-2018
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author Mylius, Caspar Frederik
Krijnen, Wilhelmus Petrus
van der Schans, Cornelis Peter
Takken, Tim
author_facet Mylius, Caspar Frederik
Krijnen, Wilhelmus Petrus
van der Schans, Cornelis Peter
Takken, Tim
author_sort Mylius, Caspar Frederik
collection PubMed
description Peak oxygen uptake (V′(O(2)peak)) is recognised as the best expression of aerobic fitness. Therefore, it is essential that V′(O(2)peak) reference values are accurate for interpreting a cardiopulmonary exercise test (CPET). These values are country specific and influenced by underlying biological ageing processes. They are normally stratified per paediatric and adult population, resulting in a discontinuity at the transition point between prediction equations. There are currently no age-related reference values available for the lifespan of individuals in the Dutch population. The aim of this study is to determine the best-fitting regression model for V′(O(2)peak) in the healthy Dutch paediatric and adult populations in relation to age. In this retrospective study, CPET cycle ergometry results of 4477 subjects without reported somatic diseases were included (907 females, age 7.9–65.0 years). Generalised additive models were employed to determine the best-fitting regression model. Cross-validation was performed against an independent dataset consisting of 3518 subjects (170 females, age 6.8–59.0 years). An additive model was the best fitting with the largest predictive accuracy in both the primary (adjusted R(2)=0.57, standard error of the estimate (see)=556.50 mL·min(−1)) and cross-validation (adjusted R(2)=0.57, see=473.15 mL·min(−1)) dataset. This study provides a robust additive regression model for V′(O(2)peak) in the Dutch population.
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spelling pubmed-64416752019-04-04 Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry Mylius, Caspar Frederik Krijnen, Wilhelmus Petrus van der Schans, Cornelis Peter Takken, Tim ERJ Open Res Original Articles Peak oxygen uptake (V′(O(2)peak)) is recognised as the best expression of aerobic fitness. Therefore, it is essential that V′(O(2)peak) reference values are accurate for interpreting a cardiopulmonary exercise test (CPET). These values are country specific and influenced by underlying biological ageing processes. They are normally stratified per paediatric and adult population, resulting in a discontinuity at the transition point between prediction equations. There are currently no age-related reference values available for the lifespan of individuals in the Dutch population. The aim of this study is to determine the best-fitting regression model for V′(O(2)peak) in the healthy Dutch paediatric and adult populations in relation to age. In this retrospective study, CPET cycle ergometry results of 4477 subjects without reported somatic diseases were included (907 females, age 7.9–65.0 years). Generalised additive models were employed to determine the best-fitting regression model. Cross-validation was performed against an independent dataset consisting of 3518 subjects (170 females, age 6.8–59.0 years). An additive model was the best fitting with the largest predictive accuracy in both the primary (adjusted R(2)=0.57, standard error of the estimate (see)=556.50 mL·min(−1)) and cross-validation (adjusted R(2)=0.57, see=473.15 mL·min(−1)) dataset. This study provides a robust additive regression model for V′(O(2)peak) in the Dutch population. European Respiratory Society 2019-04-01 /pmc/articles/PMC6441675/ /pubmed/30949491 http://dx.doi.org/10.1183/23120541.00056-2018 Text en Copyright ©ERS 2019 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Mylius, Caspar Frederik
Krijnen, Wilhelmus Petrus
van der Schans, Cornelis Peter
Takken, Tim
Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title_full Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title_fullStr Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title_full_unstemmed Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title_short Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
title_sort peak oxygen uptake reference values for cycle ergometry for the healthy dutch population: data from the lowlands fitness registry
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441675/
https://www.ncbi.nlm.nih.gov/pubmed/30949491
http://dx.doi.org/10.1183/23120541.00056-2018
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