The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific...

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Detalles Bibliográficos
Autores principales: Cooper, Robin L., McNabb, Micaiah, Nadolski, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441827/
https://www.ncbi.nlm.nih.gov/pubmed/30976700
http://dx.doi.org/10.1016/j.heliyon.2019.e01430
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author Cooper, Robin L.
McNabb, Micaiah
Nadolski, Jeremy
author_facet Cooper, Robin L.
McNabb, Micaiah
Nadolski, Jeremy
author_sort Cooper, Robin L.
collection PubMed
description The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.
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spelling pubmed-64418272019-04-11 The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction Cooper, Robin L. McNabb, Micaiah Nadolski, Jeremy Heliyon Article The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response. Elsevier 2019-03-28 /pmc/articles/PMC6441827/ /pubmed/30976700 http://dx.doi.org/10.1016/j.heliyon.2019.e01430 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Cooper, Robin L.
McNabb, Micaiah
Nadolski, Jeremy
The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title_full The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title_fullStr The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title_full_unstemmed The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title_short The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction
title_sort effects of bacterial endotoxin lps on synaptic transmission at the neuromuscular junction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441827/
https://www.ncbi.nlm.nih.gov/pubmed/30976700
http://dx.doi.org/10.1016/j.heliyon.2019.e01430
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