Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism via transcriptional regulation. However, direct metabolic targets of BRCA1 and the underlying regulatory mechanisms are still unknown. Here, we identified several metabolic genes, including the gene which encode...

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Detalles Bibliográficos
Autores principales: Hong, Ruoxi, Zhang, Weimin, Xia, Xi, Zhang, Kai, Wang, Yan, Wu, Mengjiao, Fan, Jiawen, Li, Jinting, Xia, Wen, Xu, Fei, Chen, Jie, Wang, Shusen, Zhan, Qimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441895/
https://www.ncbi.nlm.nih.gov/pubmed/30714292
http://dx.doi.org/10.1002/1878-0261.12466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441895/
https://www.ncbi.nlm.nih.gov/pubmed/30714292
http://dx.doi.org/10.1002/1878-0261.12466

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