EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized...

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Detalles Bibliográficos
Autores principales: Atkinson, Caroline J., Kawamata, Futoshi, Liu, Cheng, Ham, Sunyoung, Győrffy, Balázs, Munn, Alan L., Wei, Ming Q., Möller, Andreas, Whitehall, Vicki, Wiegmans, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441932/
https://www.ncbi.nlm.nih.gov/pubmed/30478887
http://dx.doi.org/10.1002/1878-0261.12411

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