Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

[Image: see text] Herein, a promising near-infrared-responsive photothermal agent was designed by anchoring of rice grain-shaped ZnO particles over graphene (GR) nanosheets and subsequent sensitization with cobalt phthalocyanine (CoPc). Thus, produced GR–ZnO–CoPc was able to attain the temperature of 68 °C by irradiating to 980 nm laser for 7 min, which is extremely higher than the endurance temperature of cancer cells. The linear fashioned progression in the photothermal effect of GR nanosheets was conquered by immobilization of ZnO particles and successive sensitization with CoPc. The excellence found in the photothermal effect of GR–ZnO–CoPc was verified by estimation of its photothermal conversion efficiency. The photothermal conversion efficiency assessed for GR–ZnO–CoPc was higher than those for the popular gold- and CuS-based photothermal agents. In addition, it possessed significant stability against photobleaching and structural rupture. It was found that the photothermal effect of GR–ZnO–CoPc is proportional to its concentration. However, by replacement of a 980 nm laser system with 808 nm, the photothermal effect of GR–ZnO–CoPc was reduced, which could be due to lower absorption of GR–ZnO–CoPc at 808 nm compared to 980 nm. On account of its significance and important properties, GR–ZnO–CoPc could be an interesting photothermal agent to employ in future photothermal therapy for cancer.