Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model

BACKGROUND: Graft-versus host disease (GVHD) is a complication of stem cell transplantation associated with significant morbidity and mortality. Non-specific immune-suppression, the mainstay of treatment, may result in immune-surveillance dysfunction and disease recurrence. METHODS: We created human...

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Detalles Bibliográficos
Autores principales: Ono, Rintaro, Watanabe, Takashi, Kawakami, Eiryo, Iwasaki, Makoto, Tomizawa-Murasawa, Mariko, Matsuda, Masashi, Najima, Yuho, Takagi, Shinsuke, Fujiki, Saera, Sato, Rumi, Mochizuki, Yoshiki, Yoshida, Hisahiro, Sato, Kaoru, Yabe, Hiromasa, Kato, Shunichi, Saito, Yoriko, Taniguchi, Shuichi, Shultz, Leonard D., Ohara, Osamu, Amagai, Masayuki, Koseki, Haruhiko, Ishikawa, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441951/
https://www.ncbi.nlm.nih.gov/pubmed/30772305
http://dx.doi.org/10.1016/j.ebiom.2019.02.001

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