Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation

BACKGROUND: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a...

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Detalles Bibliográficos
Autores principales: Cornett, Ashley, Athwal, Harleen K., Hill, Emily, Murphy, George, Yeoh, Kenji, Moskaluk, Christopher A., Witt, Robert L., D'Silva, Nisha J., Agarwal, Seema, Lombaert, Isabelle M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442226/
https://www.ncbi.nlm.nih.gov/pubmed/30765319
http://dx.doi.org/10.1016/j.ebiom.2019.02.011

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