Cargando…

Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression

BACKGROUND: c-Src is a driver oncogene well-known for tumorigenic signaling, but little for metabolic function. Previous reports about c-Src regulation of glucose metabolism prompted us to investigate its function in other nutrient modulation, particularly in lipid metabolism. METHODS: Oil-red O sta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hua, Tuyen N.M., Kim, Min-Kyu, Vo, Vu T.A., Choi, Jong-Whan, Choi, Jang Hyun, Kim, Hyun-Won, Cha, Seung-Kuy, Park, Kyu-Sang, Jeong, Yangsik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442332/ https://www.ncbi.nlm.nih.gov/pubmed/30755372 http://dx.doi.org/10.1016/j.ebiom.2019.02.015

Ejemplares similares

PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2017)

Correction: PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2019)

Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2016)

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion
por: Prentice, Kacey J., et al.
Publicado: (2023)

Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
por: Chang, Jae Seung, et al.
Publicado: (2020)

Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment
por: Vo, Vu T. A., et al.
Publicado: (2022)

Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients
por: Hua, Tuyen N. M., et al.
Publicado: (2020)

LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma
por: Kim, Min-Kyu, et al.
Publicado: (2020)

Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion
por: Inouye, Karen E., et al.
Publicado: (2023)

Impact of Lifestyle Behaviors on Cancer Risk and Prevention
por: Choi, Jong-Whan, et al.
Publicado: (2021)

The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial‐to‐mesenchymal transition and lipid‐derived energy production in prostate cancer cells
por: Liu, Rong‐Zong, et al.
Publicado: (2020)

Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis
por: Kim, Jihye, et al.
Publicado: (2015)

Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling
por: Kim, Ji-Hee, et al.
Publicado: (2021)

Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes
por: Kim, Sang-Nam, et al.
Publicado: (2017)

Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis
por: Yamada, Yoko, et al.
Publicado: (2015)

Novel Function of α-Cubebenoate Derived from Schisandra chinensis as Lipogenesis Inhibitor, Lipolysis Stimulator and Inflammasome Suppressor
por: Bae, Su Ji, et al.
Publicado: (2020)

FABP1 and FABP2 as markers of diabetic nephropathy
por: Tsai, I-Ting, et al.
Publicado: (2020)

Biological Role of Anti-aging Protein Klotho
por: Kim, Ji-Hee, et al.
Publicado: (2015)

Epinephrine minimizes the use of bipolar coagulation and preserves ovarian reserve in laparoscopic ovarian cystectomy: a randomized controlled trial
por: Park, Eun Young, et al.
Publicado: (2020)

Historical retrospective of the SRC oncogene and new perspectives (Review)
por: Simatou, Aristofania, et al.
Publicado: (2020)

nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer
por: Lee, Eun Kyung, et al.
Publicado: (2016)

Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function
por: Berdeaux, Rebecca L., et al.
Publicado: (2004)

Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue
por: Son, Yeonho, et al.
Publicado: (2020)

Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPARγ in 3T3-L1 Cells
por: Lee, Mina, et al.
Publicado: (2016)

Effects of EPA supplementation on plasma fatty acids composition in hypertriglyceridemic subjects with FABP2 and PPARα genotypes
por: Pishva, Hamideh, et al.
Publicado: (2012)

FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway
por: Zhuang, Lingfang, et al.
Publicado: (2021)

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015)

Amidation-Modified Apelin-13 Regulates PPARγ and Perilipin to Inhibit Adipogenic Differentiation and Promote Lipolysis
por: Wang, Sha, et al.
Publicado: (2021)

Hyperphosphorylated PTEN exerts oncogenic properties
por: van Ree, Janine H., et al.
Publicado: (2023)

High expression of FABP4 and FABP6 in patients with colorectal cancer
por: Zhang, Yaqin, et al.
Publicado: (2019)

DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis
por: Abbasi, Nazia, et al.
Publicado: (2020)

Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue
por: Park, Sujeong, et al.
Publicado: (2021)

EPS8 phosphorylation by Src modulates its oncogenic functions
por: Shahoumi, Linah A., et al.
Publicado: (2020)

AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
por: Shin, Jae Hoon, et al.
Publicado: (2016)

Morusin Functions as a Lipogenesis Inhibitor as Well as a Lipolysis Stimulator in Differentiated 3T3-L1 and Primary Adipocytes
por: Lee, Mi Rim, et al.
Publicado: (2018)

A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes
por: Lamas Bervejillo, M., et al.
Publicado: (2019)

Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway
por: Chen, Nan-Nan, et al.
Publicado: (2023)

ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway
por: Cao, Yanlin, et al.
Publicado: (2023)

Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome
por: Kim, Ji-Hee, et al.
Publicado: (2016)

Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer
por: Kim, Su-Jeong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m8re9la2fcombe3o3rmlrpel45