CG dinucleotides enhance promoter activity independent of DNA methylation

Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is unknown to what extent the CpG dinucleotide itself actually contributes to promoter activity. To address this question, we...

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Detalles Bibliográficos
Autores principales: Hartl, Dominik, Krebs, Arnaud R., Grand, Ralph S., Baubec, Tuncay, Isbel, Luke, Wirbelauer, Christiane, Burger, Lukas, Schübeler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442381/
https://www.ncbi.nlm.nih.gov/pubmed/30709850
http://dx.doi.org/10.1101/gr.241653.118

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