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Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study

Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone rege...

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Autores principales: Xia, Lunguo, Ma, Wudi, Zhou, Yuning, Gui, Zhipeng, Yao, Aihua, Wang, Deping, Takemura, Akimichi, Uemura, Mamoru, Lin, Kailin, Xu, Yuanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442456/
https://www.ncbi.nlm.nih.gov/pubmed/31011582
http://dx.doi.org/10.1155/2019/8961409
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author Xia, Lunguo
Ma, Wudi
Zhou, Yuning
Gui, Zhipeng
Yao, Aihua
Wang, Deping
Takemura, Akimichi
Uemura, Mamoru
Lin, Kailin
Xu, Yuanjin
author_facet Xia, Lunguo
Ma, Wudi
Zhou, Yuning
Gui, Zhipeng
Yao, Aihua
Wang, Deping
Takemura, Akimichi
Uemura, Mamoru
Lin, Kailin
Xu, Yuanjin
author_sort Xia, Lunguo
collection PubMed
description Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigated with different B-BG contents (0, 10, 20, 30, and 40 wt.%), in order to evaluate the potential applications of B-BG/PCL composites for bone regeneration. The results showed that the B-BG/PCL composites possess better tensile strength, human neutral pH value, and fast degradation as compared to pure PCL polymers. Moreover, the incorporation of B-BG could enhance proliferation, osteogenic differentiation, and angiogenic factor expression for rat bone marrow stromal cells (rBMSCs) as compared to pure PCL polymers. Importantly, the B-BG also promoted the angiogenic differentiation for human umbilical vein endothelial cells (HUVECs). These enhanced effects had a concentration dependence of B-BG content, while 30 wt.% B-BG/PCL composites achieved the greatest stimulatory effect. Therefore the 30 wt.% B-BG/PCL composites have potential applications in bone reconstruction fields.
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spelling pubmed-64424562019-04-22 Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study Xia, Lunguo Ma, Wudi Zhou, Yuning Gui, Zhipeng Yao, Aihua Wang, Deping Takemura, Akimichi Uemura, Mamoru Lin, Kailin Xu, Yuanjin Biomed Res Int Research Article Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigated with different B-BG contents (0, 10, 20, 30, and 40 wt.%), in order to evaluate the potential applications of B-BG/PCL composites for bone regeneration. The results showed that the B-BG/PCL composites possess better tensile strength, human neutral pH value, and fast degradation as compared to pure PCL polymers. Moreover, the incorporation of B-BG could enhance proliferation, osteogenic differentiation, and angiogenic factor expression for rat bone marrow stromal cells (rBMSCs) as compared to pure PCL polymers. Importantly, the B-BG also promoted the angiogenic differentiation for human umbilical vein endothelial cells (HUVECs). These enhanced effects had a concentration dependence of B-BG content, while 30 wt.% B-BG/PCL composites achieved the greatest stimulatory effect. Therefore the 30 wt.% B-BG/PCL composites have potential applications in bone reconstruction fields. Hindawi 2019-03-18 /pmc/articles/PMC6442456/ /pubmed/31011582 http://dx.doi.org/10.1155/2019/8961409 Text en Copyright © 2019 Lunguo Xia et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xia, Lunguo
Ma, Wudi
Zhou, Yuning
Gui, Zhipeng
Yao, Aihua
Wang, Deping
Takemura, Akimichi
Uemura, Mamoru
Lin, Kailin
Xu, Yuanjin
Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title_full Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title_fullStr Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title_full_unstemmed Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title_short Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
title_sort stimulatory effects of boron containing bioactive glass on osteogenesis and angiogenesis of polycaprolactone: in vitro study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442456/
https://www.ncbi.nlm.nih.gov/pubmed/31011582
http://dx.doi.org/10.1155/2019/8961409
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