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Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture
Congenital pseudarthrosis of the tibia (CPT) is likely to be a primary periosteal disease and secondary bone disease. The primary goal of treatment is to obtain union, correct the diaphyseal deformity, correct any proximal fibular migration and prevent refracture. The pathobiology demonstrates incre...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The British Editorial Society of Bone & Joint Surgery
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442511/ https://www.ncbi.nlm.nih.gov/pubmed/30996736 http://dx.doi.org/10.1302/1863-2548.13.180147 |
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author | Paley, D. |
author_facet | Paley, D. |
author_sort | Paley, D. |
collection | PubMed |
description | Congenital pseudarthrosis of the tibia (CPT) is likely to be a primary periosteal disease and secondary bone disease. The primary goal of treatment is to obtain union, correct the diaphyseal deformity, correct any proximal fibular migration and prevent refracture. The pathobiology demonstrates increased osteoclasis by the surrounding fibrous hamartoma and reduced osteogenesis and bone morphogenic protein production by the bone. This leads to a loss of remodelling potential and gradual bowing and atrophy of the bone with eventual fracture of the tibia and or fibula. This recommends the synergistic use of bisphosphonates and bone morphogenic protein. The pathomechanics of CPT implicate the anterolateral bowing, narrow diameter of the atrophic bone ends and proximal fibular migration. These biomechanical factors can be addressed by means of straightening of the deformity, intramedullary support of both bones, stable fixation and reduction of proximal migration of the fibula. A summary of the literature on CPT shows that the mean probability of achieving primary union without refracture, by most treatments is 50% (12% to 80%). Two recent studies have shown a much higher success rate approaching 100%, by creating a cross-union between the tibia and fibula. The cross-union with intramedullary reinforcement of the bone makes refracture unlikely due to the cross-sectional area of union with its two-bar linkage. A new classification to guide such treatment is also proposed. LEVEL OF EVIDENCE: V – expert opinion |
format | Online Article Text |
id | pubmed-6442511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The British Editorial Society of Bone & Joint Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-64425112019-04-17 Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture Paley, D. J Child Orthop Current Concepts Review Congenital pseudarthrosis of the tibia (CPT) is likely to be a primary periosteal disease and secondary bone disease. The primary goal of treatment is to obtain union, correct the diaphyseal deformity, correct any proximal fibular migration and prevent refracture. The pathobiology demonstrates increased osteoclasis by the surrounding fibrous hamartoma and reduced osteogenesis and bone morphogenic protein production by the bone. This leads to a loss of remodelling potential and gradual bowing and atrophy of the bone with eventual fracture of the tibia and or fibula. This recommends the synergistic use of bisphosphonates and bone morphogenic protein. The pathomechanics of CPT implicate the anterolateral bowing, narrow diameter of the atrophic bone ends and proximal fibular migration. These biomechanical factors can be addressed by means of straightening of the deformity, intramedullary support of both bones, stable fixation and reduction of proximal migration of the fibula. A summary of the literature on CPT shows that the mean probability of achieving primary union without refracture, by most treatments is 50% (12% to 80%). Two recent studies have shown a much higher success rate approaching 100%, by creating a cross-union between the tibia and fibula. The cross-union with intramedullary reinforcement of the bone makes refracture unlikely due to the cross-sectional area of union with its two-bar linkage. A new classification to guide such treatment is also proposed. LEVEL OF EVIDENCE: V – expert opinion The British Editorial Society of Bone & Joint Surgery 2019-04-01 /pmc/articles/PMC6442511/ /pubmed/30996736 http://dx.doi.org/10.1302/1863-2548.13.180147 Text en Copyright © 2019, The author(s) http://creativecommons.org/licenses/by-nc/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed. |
spellingShingle | Current Concepts Review Paley, D. Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title | Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title_full | Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title_fullStr | Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title_full_unstemmed | Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title_short | Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
title_sort | congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture |
topic | Current Concepts Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442511/ https://www.ncbi.nlm.nih.gov/pubmed/30996736 http://dx.doi.org/10.1302/1863-2548.13.180147 |
work_keys_str_mv | AT paleyd congenitalpseudarthrosisofthetibiabiologicalandbiomechanicalconsiderationstoachieveunionandpreventrefracture |