Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study

BACKGROUND: Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic factor receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it is a promising therapeutic targe...

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Detalles Bibliográficos
Autores principales: Cheung, Ching-Lung, Tan, Kathryn C.B., Au, Philip C.M., Li, Gloria H.Y., Cheung, Bernard M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442643/
https://www.ncbi.nlm.nih.gov/pubmed/30772304
http://dx.doi.org/10.1016/j.ebiom.2019.02.021

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